The same year, the 16-year-old Philibert married the 9-year-old Yolande Louise of Savoy, his cousin and the only sister of the deceased young duke. She was daughter of Duke Charles I of Savoy, the Warrior, and Blanche of Montferrat, as well as granddaughter of Philibert's late uncle, Duke Amadeus IX of Savoy. She was the heir-general of her brother, father, grandfather, and her grandmother Yolande of France, the eldest surviving daughter of king Charles VII of France. Her birthright, after the death of her brother, was the succession of the kingdoms of Cyprus, Jerusalem, and Armenia although Philibert's father took those titles.
After a brief reign, Philip II died in 1497 and Philibert succeeded as Duke of Savoy. The young couple then at last advanced their claims, and took the titles Queen and King of Cyprus, Jerusalem and Armenia.
In 1499, the 12-year-old first wife of Philibert died, childless. Her heir was her first cousin, Princess Charlotte of Naples, later Countess of Laval. Philibert continued to use the titles of Cyprus etc., despite the death of his first wife.
Early in Philibert's reign, his first cousin Charles VIII of France died in 1498. The next king, Louis XII, would invade Italy the following year and conquer most of Naples. Louis would also conquer Milan, which neighboured Savoy to the east, thus putting the Savoyards between French possessions.
Philibert died in 1504 at the age of 24. Because he had no children, he was succeeded by his young half-brother Charles III.