Indian Institute of ScienceSir William Richard Gowers Parkinson Disease sketch 1886
Patrick D'Silva serves as an associate professor at the Division of Biological Sciences of the Indian Institute of Science[2] and heads the Molecular Chaperone Lab as its principal investigator.[3] His research focus is on the cell biological aspects of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease as well as various cancers and his team is known to have made several breakthroughs in the treatment of such diseases.[4] In 2015, D'Silva led a research which identified that Hsp31, a stress response chaperone, in Yeast provided abioticstress tolerance to the fungus.[5] On further studies, he found out that the chaperone acts as a detoxifier by removing a toxic metabolite named Methylglyoxal (MG) and regulates reactive oxygen species (ROS).[6] This led to further investigations and DJ-1, a protein similar to Hsp31, helped to enhance natural detoxifiers such as glutathione (GSH) which in turn regulated the reactive oxygen species and this discovery promised to offer new ways in the management of some forms of Parkinson's disease.[4]
Later, D'Silva and his team furthered their research and developed a metal oxidenanomaterial, which when introduced into humans, acted similar to three major cellular antioxidant enzymes which regulated the level of reactive oxygen species inside cells.[7][8] This nanomaterial, made of vanadia, exhibited glutathione peroxidase enzyme activity, thus proving to be a nanozyme and it was the first time identification that all three major antioxidant enzymes in one nanozyme.[9] This discovery is reported to have uses in drug development in cardiac disorders, and neurodegenrative diseases like Parkinson's and Alzheimer's disease.[10][11] D'Silva's studies have been documented by way of a number of articles[note 1] and ResearchGate, an online repository of scientific articles has listed 57 of them.[12] He also hosts several post-doctoral and doctoral researchers at his laboratory.[13]
Singh, Namrata; Savanur, Mohammed Azharuddin; Srivastava, Shubhi; D'Silva, Patrick; Mugesh, Govindasamy (4 October 2017). "A Redox Modulatory Mn3O4 Nanozyme with Multi-Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model". Angewandte Chemie International Edition. 56 (45): 14267–14271. doi:10.1002/anie.201708573. PMID28922532.
Melvin, Prasad; Bankapalli, Kondalarao; D’Silva, Patrick; Shivaprasad, P. V. (1 July 2017). "Methylglyoxal detoxification by a DJ-1 family protein provides dual abiotic and biotic stress tolerance in transgenic plants". Plant Molecular Biology. 94 (4–5): 381–397. doi:10.1007/s11103-017-0613-9. PMID28444544. S2CID22522772.
