PSMA8

PSMA8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4R3O, 4R67
Identifiers
Aliases	PSMA8, PSMA7L, proteasome subunit alpha 8, proteasome 20S subunit alpha 8
External IDs	OMIM: 617841; MGI: 1920927; HomoloGene: 2086; GeneCards: PSMA8; OMA:PSMA8 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q11.2 Start 26,133,852 bp[1] End 26,193,355 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 14,839,208 bp[2] End 14,895,358 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis sperm left testis testicle buccal mucosa cell gonad lymph node granulocyte appendix pharynx Top expressed in spermatocyte spermatid seminiferous tubule blastocyst embryo embryo endocardial cushion atrioventricular valve morula Gonadal ridge More reference expression data BioGPS n/a
Gene ontology Molecular function endopeptidase activity peptidase activity threonine-type endopeptidase activity hydrolase activity Cellular component cytoplasm cytosol spermatoproteasome complex proteasome complex extracellular exosome nucleus proteasome core complex proteasome core complex, alpha-subunit complex Biological process regulation of cellular amino acid metabolic process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent regulation of mRNA stability ubiquitin-dependent protein catabolic process positive regulation of canonical Wnt signaling pathway protein polyubiquitination stimulatory C-type lectin receptor signaling pathway tumor necrosis factor-mediated signaling pathway MAPK cascade proteolysis Fc-epsilon receptor signaling pathway NIK/NF-kappaB signaling anaphase-promoting complex-dependent catabolic process proteolysis involved in cellular protein catabolic process T cell receptor signaling pathway negative regulation of canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of G2/M transition of mitotic cell cycle protein deubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process transmembrane transport regulation of transcription from RNA polymerase II promoter in response to hypoxia post-translational protein modification regulation of hematopoietic stem cell differentiation proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process interleukin-1-mediated signaling pathway regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 143471 73677 Ensembl ENSG00000154611 ENSMUSG00000036743 UniProt Q8TAA3 Q9CWH6 RefSeq (mRNA) NM_001025096 NM_001025097 NM_001308188 NM_144662 NM_001163609 NM_001360823 RefSeq (protein) NP_001020267 NP_001020268 NP_001295117 NP_653263 NP_001157081 NP_001347752 Location (UCSC) Chr 18: 26.13 – 26.19 Mb Chr 18: 14.84 – 14.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Proteasome subunit alpha 8 also known as proteasome subunit alpha type-7-like is a protein that in humans is encoded by the PSMA8 gene.^[5] Proteasome subunit alpha 8 is a component of the sperm specific proteasome.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000154611 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036743 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PSMA8 proteasome subunit alpha 8".
6. de Mateo S, Castillo J, Estanyol JM, Ballescà JL, Oliva R (2011). "Proteomic characterization of the human sperm nucleus". Proteomics. 11 (13): 2714–26. doi:10.1002/pmic.201000799. PMID 21630459. S2CID 9305926.