POLR3B

55703

POLR3B
POLR3B
Identifiers
AliasesPOLR3B, C128, HLD8, INMAP, RPC2, polymerase (RNA) III subunit B, RNA polymerase III subunit B, CMT1I
External IDsOMIM: 614366; MGI: 1917678; GeneCards: POLR3B
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
2.7.7.6↗↗↗↗
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

55703

70428

Ensembl

ENSG00000013503

ENSMUSG00000034453

UniProt

Q9NW08

P59470

RefSeq (mRNA)

NM_018082
NM_001160708

NM_027423

RefSeq (protein)

NP_001154180
NP_060552

NP_081699

Location (UCSC)Chr 12: 106.36 – 106.51 MbChr 10: 84.46 – 84.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RNA polymerase III subunit B is an enzyme that in humans is encoded by the POLR3B gene. It is the second largest subunit of RNA polymerase III.[5] Subunit B is part of the catalytic center of the RNA polymerase III complex.[6]

Gene

The POLR3B gene is located on the long arm (q) of chromosome 12 on position 23.3, from base pair from base pair 106,357,748 to base pair 106,510,198.[7]

Function

RNA polymerase III is an essential enzyme complex responsible for synthesizing small non-coding RNAs, including transfer RNAs (tRNAs) and 5S ribosomal RNA (rRNA) and these small RNAs play a critical role in the process of protein synthesis within cells.[8]

Clinical significance

Mutations in POLR3B are associated with certain genetic disorders, such as 4H leukodystrophy and Charcot–Marie–Tooth disease type 1I.[8][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000013503 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034453 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "POLYMERASE III, RNA, SUBUNIT B; POLR3B". omim.org.
  6. ^ Watt KE, Macintosh J, Bernard G, Trainor PA (February 2023). "RNA Polymerases I and III in development and disease". Seminars in Cell & Developmental Biology. 136: 49–63. doi:10.1016/j.semcdb.2022.03.027. PMC 9550887. PMID 35422389.
  7. ^ "POLR3B RNA polymerase III subunit B [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2025-07-31.
  8. ^ a b "POLR3B gene: MedlinePlus Genetics". MedlinePlus. U.S. National Library of Medicine.
  9. ^ Lata E, Choquet K, Sagliocco F, Brais B, Bernard G, Teichmann M (2021). "RNA Polymerase III Subunit Mutations in Genetic Diseases". Frontiers in Molecular Biosciences. 8 696438. doi:10.3389/fmolb.2021.696438. PMC 8362101. PMID 34395528.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.