PDE6C

PDE6C
Identifiers
Aliases	PDE6C, ACHM5, COD4, PDEA2, phosphodiesterase 6C
External IDs	OMIM: 600827; MGI: 105956; GeneCards: PDE6C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JWQ, 3JWR, 5E8F
Enzyme activity
Gene location (Human)
Chr.	Chromosome 10 (human)
End	93,666,010 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	38,172,406 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; testicle; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; ectocervix; ; tibial nerve; ; right lung; ; gastrocnemius muscle; ; canal of the cervix; ; body of uterus;
	Top expressed in
	neural layer of retina; ; pineal gland; ; epithelium of lens; ; yolk sac; ; retinal pigment epithelium; ; choroid plexus of fourth ventricle; ; embryo; ; liver; ; primitive streak; ; iris;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphoric diester hydrolase activity; nucleotide binding; cGMP binding; 3',5'-cyclic-GMP phosphodiesterase activity; hydrolase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; metal ion binding;
Cellular component	plasma membrane; membrane;
Biological process	sensory perception of light stimulus; retinal cone cell development; signal transduction; visual perception; phototransduction of visible light; response to stimulus;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5146
	110855
	ENSG00000095464
	ENSMUSG00000024992
	P51160
	Q91ZQ1
	NM_006204
	NM_001170959; NM_033614
	NP_006195
	NP_001164430; NP_291092
	Wikidata
View/Edit Human	View/Edit Mouse

Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' is an enzyme that in humans is encoded by the PDE6C gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000095464 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024992 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime".

Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–381. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bertazolli-Filho R, Ghosh S, Huang W, et al. (2001). "Molecular evidence that human ocular ciliary epithelium expresses components involved in phototransduction". Biochem. Biophys. Res. Commun. 284 (2): 317–325. doi:10.1006/bbrc.2001.4970. PMID 11394879.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–445. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Gao YQ, Danciger M, Longmuir R, et al. (1999). "Screening of the gene encoding the alpha'-subunit of cone cGMP-PDE in patients with retinal degenerations". Invest. Ophthalmol. Vis. Sci. 40 (8): 1818–1822. PMID 10393054.
Feshchenko EA, Andreeva SG, Suslova VA, et al. (1996). "Human cone-specific cGMP phosphodiesterase alpha' subunit: complete cDNA sequence and gene arrangement". FEBS Lett. 381 (1–2): 149–152. doi:10.1016/0014-5793(96)00104-4. PMID 8641425. S2CID 86278856.
Viczian AS, Piriev NI, Farber DB (1996). "Isolation and characterization of a cDNA encoding the alpha' subunit of human cone cGMP-phosphodiesterase". Gene. 166 (2): 205–211. doi:10.1016/0378-1119(95)00585-4. PMID 8543163.
Piriev NI, Viczian AS, Ye J, et al. (1996). "Gene structure and amino acid sequence of the human cone photoreceptor cGMP-phosphodiesterase alpha' subunit (PDEA2) and its chromosomal localization to 10q24". Genomics. 28 (3): 429–435. doi:10.1006/geno.1995.1171. PMID 7490077.

External links

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000095464 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024992 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime".

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PDE6C

References

Further reading

External links

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