An oxo-Diels–Alder reaction (also called an oxa-Diels–Alder reaction) is an organic reaction and a variation of the Diels–Alder reaction in which a suitable diene reacts with an aldehyde to form a dihydropyran ring. This reaction is of some importance to synthetic organic chemistry.
![Oxo Diels–Alder reaction general](//upload.wikimedia.org/wikipedia/commons/thumb/3/3d/Oxo-Diels_Alder_general.svg/368px-Oxo-Diels_Alder_general.svg.png)
The oxo-DA reaction was first reported in 1949[1] using a 2-methylpenta-1,3-diene and formaldehyde as reactants.
![Oxo Diels–Alder reaction Gresham 1949](//upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Oxo_Diels_Alder_reaction_Gresham_1949.svg/333px-Oxo_Diels_Alder_reaction_Gresham_1949.svg.png)
Asymmetric oxo-DA reactions (including catalytic reactions) are well known.[2] Many strategies rely on coordinating a chiral Lewis acid to the carbonyl group.
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