Targhalline began his career at the Mohammed VI Academy in Salé, Morocco[1] before signing his first professional contract with Marseille at the age of 18. He scored his first senior goal for the club in a mid-season friendly match against Nîmes; Marseille went on to win the match 4–1.[2] Targhalline made his first-team competitive debut for Marseille in a 4–1 Coupe de France win over Cannet Rocheville on 19 December 2021.[3] He made his Ligue 1 debut in a 1–0 win over Bordeaux on 7 January 2022.[4] On 1 August 2022, Targhalline was loaned to Turkish side Alanyaspor.[5]
On 7 January 2023, after being recalled from the loan spell, Targhalline joined Ligue 2 side Le Havre on a permanent deal, signing a contract until June 2025, with an option for another year.[6][7]