Ottavio Accoramboni was born in Rome in the first months of 1549, into a family of Gubbio. He studied at the Roman College by the Jesuits and at the University of Padua.[1] His younger sister, Vittoria, married in 1573 Francesco Peretti, a nephew of Cardinal Montalto, who supported the ecclesiastic career of Ottavio. On 15 May 1579 he was appointed bishop of Fossombrone in the Duchy of Urbino.[2] His episcopal consecration followed on 8 June in the Sistine Chapel by the hands of cardinal Benedetto Lomellini.[3]
He remained unrelated to the bloody events which involved his sister Vittoria. Ottavio resigned from his bishopric in 1610 and returned to live in Rome.[1]
On 4 June 1614, he was appointed Apostolic Nuncio to Portugal.[4] In Portugal Ottavio supported the action of the Jesuits in the Far East, and introduced the cult of Charles Borromeo and Frances of Rome: in particular on 27 June 1616 he organized a procession by boats from Aldeia Galega to Lisbon in honor of Saint Charles.[5] The other main effort of Ottavio was to defend the interests of the Church and in particular he opposed the law that required a permit of the king for the ecclesiastics to buy real estates. To sanction violations of the Church's jurisdiction, on 27 June 1617 he imposed a general interdict in Portugal, which was left only on 30 May of the following year after the intervention of Rome.[5]
On 4 June 1620 Vincenzo Landinelli was appointed as Nuncio in his place,[4] but Ottavio remained in Portugal until the end of 1622.[5]
On 17 May 1621, he had been appointed Archbishop of Urbino,[6] however he resigned in 1623 for health problems. He died in Rome on 23 May 1625,[1] and he was buried in the church of San Gregorio al Celio. On about 1672 his relatives moved his tomb to the new erected family chapel in Sant'Andrea delle Fratte.