Oscillibacter valericigenes

Oscillibacter valericigenes
Scientific classification
Domain:
Bacteria
Phylum:
Bacillota
Class:
Clostridia
Order:
Eubacteriales
Family:
Oscillospiraceae
Genus:
Oscillibacter
Species:
O. valericigenes
Binomial name
Oscillibacter valericigenes
Iino et al. 2007[1]

Oscillibacter valericigenes is a species of mesophilic bacterium identified in the alimentary canal of Japanese Corbicula clams. It is Gram-negative and anaerobic, with a straight to slightly curved rod-like morphology, and is motile with petritrichous flagella (i.e., flagella with diverse orientations from the cell body). It was not observed in culture to form spores. [2]

Phylogenetic relationships

Based on sequencing of 16S rRNA, O. valericigenes is a member of the clostridial cluster IV, a subgroup of clostridial bacteria typically found in the alimentary canals of animals, including humans. Its closest cultured relatives at the time of its original description in 2007 were Clostridium orbiscindens (found in human feces) and Clostridium viride. It also exhibits a close relationship to Oscillospira guillermondii, a large bacterial species found in the guts of ruminant animals, which has yet to be grown in culture despite having been first observed in 1913.[2]

O. valericigenes is unusual in that its 16S rRNA more closely resembles that of uncultured bacteria in animal digestive tracts than the other cultured members of clostridial cluster IV. Its genome was sequenced in 2012 and found to contain some genes identifiably homologous to those known to be involved in sporulation; however, it is missing many genes involved in the later stages of sporulation that are widely distributed among clostridial bacteria.[3]

Metabolism

O. valericigenes grows fermentatively, producing predominantly valerate when grown on a glucose carbon source. The bacteria were observed to grow in culture using D-glucose, L-arabinose, D-ribose, and D-xylose as carbon sources.[2]

Clinical significance

O. valericigenes has been detected in the human intestinal microbiome. In one study of human gut microflora, O. valericigenes was found in significantly more samples from healthy control test subjects than from patients diagnosed with Crohn's disease.[4][5]

References

  1. ^ A.C. Parte. "Oscillibacter". LPSN. Retrieved 2016-08-18.
  2. ^ a b c Iino, T; Mori, K; Tanaka, K; Suzuki, K; Harayama, S (August 2007). "Oscillibacter valericigenes gen. nov., sp. nov., a valerate-producing anaerobic bacterium isolated from the alimentary canal of a Japanese corbicula clam". International Journal of Systematic and Evolutionary Microbiology. 57 (Pt 8): 1840–5. doi:10.1099/ijs.0.64717-0. PMID 17684268.
  3. ^ Katano, Y; Fujinami, S; Kawakoshi, A; Nakazawa, H; Oji, S; Iino, T; Oguchi, A; Ankai, A; Fukui, S; Terui, Y; Kamata, S; Harada, T; Tanikawa, S; Suzuki, K; Fujita, N (30 July 2012). "Complete genome sequence of Oscillibacter valericigenes Sjm18-20(T) (=NBRC 101213(T))". Standards in Genomic Sciences. 6 (3): 406–14. doi:10.4056/sigs.2826118. PMC 3558957. PMID 23408234.
  4. ^ Mondot, S; Kang, S; Furet, JP; Aguirre de Carcer, D; McSweeney, C; Morrison, M; Marteau, P; Doré, J; Leclerc, M (January 2011). "Highlighting new phylogenetic specificities of Crohn's disease microbiota" (PDF). Inflammatory Bowel Diseases. 17 (1): 185–92. doi:10.1002/ibd.21436. PMID 20722058. S2CID 17061718.
  5. ^ Man, SM; Kaakoush, NO; Mitchell, HM (March 2011). "The role of bacteria and pattern-recognition receptors in Crohn's disease". Nature Reviews. Gastroenterology & Hepatology. 8 (3): 152–68. doi:10.1038/nrgastro.2011.3. PMID 21304476. S2CID 14009791.


Stub icon

This Clostridiales-related article is a stub. You can help Wikipedia by expanding it.