The first Las Vegas Wranglers game at the Orleans Arena was on October 10, 2003, where a crowd of 2,817 saw the Wranglers defeat the Bakersfield Condors, 4–2, in an exhibition game.[11][12]
The Stanley Cup visited Orleans Arena on November 25, 2005.[13]
In November 2006, the arena began hosting the Las Vegas Invitational, a pre-season college basketball tournament. It was the first event of its kind to be held at a venue connected to a casino with a sports book, the Las Vegas (College Basketball) Invitational on November 22–26, 2006.[14] The West Coast Conference has held its basketball tournaments for men and women at the venue since 2009, the first Division I conference tournament to do so at that type of venue.[15] The Western Athletic Conference has held its men's and women's tournaments at Orleans Arena since 2011.[16]
From February 26–28, 2009, the NIAA State Basketball Championship was held at the Orleans Arena. All classifications (1A–4A) attended and played at the venue.
On November 26, 2011, the UNLV men's basketball team upset No. 1 ranked North Carolina at the arena.[17]
On February 5, 2012, the arena played host to the LFL Lingerie Bowl IX. Los Angeles defeated Philadelphia 28–6.
Between July and October 2015, Global Force Wrestling taped the pilot episodes of its planned TV series GFW Amped at the Orleans Arena.[18]
On November 5, 2022, ABS-CBN's noontime variety show ASAP staged a concert live at the Orleans Arena. It was the show's first international show since the onset of the COVID-19 pandemic's lockdowns.
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