Coipel came to prominence and significant controversy as the artist of the American DC Comics book Legion of Super-Heroes during the tenure of writers Dan Abnett and Andy Lanning,[3] beginning with the "Legion of the Damned" story arc.
One of Coipel's first major works at Marvel was House of M, an eight-issue New Avengers/X-Mencrossoverlimited series with writer Brian Michael Bendis. Coipel was then announced as artist on a new Thorongoing series that launched in July 2007 with writer J. Michael Straczynski. The title was nominated for an Eisner in 2009 in the category for Best Continuing Series.[5] Coipel left the title in 2009 when it was announced Straczynski would be leaving. Coipel re-teamed with Bendis for the four-issue 2009 Marvel Comics event series Siege. In 2010, he provided art for a Magneto-focused backup story leading into the Young Avengers miniseries Avengers: the Children's Crusade, before returning to Thor in 2011, illustrating the first arc on Matt Fraction's The Mighty Thor.[6]
On April 9, 2011 Coipel was one of 62 comics creators who appeared at the IGN stage at the Kapow! convention in London to set two Guinness World Records, the Fastest Production of a Comic Book, and Most Contributors to a Comic Book. With Guinness officials on hand to monitor their progress, writer Mark Millar began work at 9am scripting a 20-page black and white Superior comic book, with Coipel and the other artists appearing on stage throughout the day to work on the pencils, inks, and lettering, including Dave Gibbons, Frank Quitely, John Romita Jr., Jock,[7]Doug Braithwaite, Ian Churchill, Duncan Fegredo, Simon Furman, David Lafuente, John McCrea, Sean Phillips and Liam Sharp,[8] who all drew a panel each, with regular Superior artist Leinil Yu creating the book's front cover. The book was completed in 11 hours, 19 minutes, and 38 seconds, and was published through Icon on November 23, 2011, with all royalties being donated to Yorkhill Children's Foundation.[7]
In 2012, Coipel penciled issues #6–7 and #11 of the Marvel crossover miniseries Avengers vs. X-Men. Coipel drew issues 9–11 and 14 of The Amazing Spider-Man, which were published in 2014.
In November 2016 Coipel and writer Jason Aaron started the series The Unworthy Thor. The series follows the original Thor, who now refers to himself as Odinson, as he tries to find his purpose after relinquishing his name and title to Foster.[9]