A'zion is from Los Angeles and also spent parts of her childhood in Boston and Neufahrn, Germany.[4] She is the daughter of actress Pamela Adlon and German director Felix Adlon [de], and the middle child between Gideon Adlon and Valentine "Rocky" Adlon.[5] Her paternal grandfather is German filmmaker Percy Adlon and her maternal grandfather was American writer-producer Don Segall, who was born to a Jewish family; her English maternal grandmother, originally an Anglican, converted to Judaism.[6]
She was initially credited as Odessa Adlon. A'zion landed her first notable role in 2017 as Liv in season 5 of Nashville.[8] Her film roles include the 2018 film Ladyworld and the 2020 one-shot horror film Let's Scare Julie.[9][10] She appeared in 2 episodes of Wayne.
A'zion landed her first main role as Shannon, the younger sister of Nina Dobrev's character, in the 2019 CBS sitcom Fam.[11] In October 2019, it was announced A'zion would star as Joey Del Marco, the lead character from Slut: The Play, in the 2020 Netflix series Grand Army.[12][13] She and Odley Jean received critical acclaim for their performances.[14]
A'zion has upcoming roles in the films Hell House and For the Night. In December 2021, she was cast in Fresh Kills written and directed by Jennifer Esposito, who will also star.[15]