OR5P3

OR5P3
Identifiers
Aliases	OR5P3, JCG1, olfactory receptor family 5 subfamily P member 3
External IDs	MGI: 3030342; HomoloGene: 72039; GeneCards: OR5P3; OMA:OR5P3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 7,824,818 bp[1] End 7,830,840 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 108,229,201 bp[2] End 108,230,835 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg urinary bladder lactiferous gland n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity odorant binding olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 120066 258769 Ensembl ENSG00000182334 ENSG00000280808 ENSG00000278253 ENSMUSG00000063764 UniProt Q8WZ94 Q8VG42 RefSeq (mRNA) NM_153445 NM_146773 RefSeq (protein) NP_703146 NP_666984 Location (UCSC) Chr 11: 7.82 – 7.83 Mb Chr 7: 108.23 – 108.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 5P3 is a protein that in humans is encoded by the OR5P3 gene.^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[5]

Ligands

The OR5P3 receptor is associated with examples of ligands includes:^[6][7]

• 1-octanol
• celery ketone
• (-)-carvone

See also

• Olfactory receptor

References

1. ENSG00000280808, ENSG00000278253 GRCh38: Ensembl release 89: ENSG00000182334, ENSG00000280808, ENSG00000278253 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063764 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR5P3 olfactory receptor, family 5, subfamily P, member 3".
6. Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi:10.1371/journal.pone.0093037. PMC 3973694. PMID 24695519.
7. Sanz G, Thomas-Danguin T, Hamdani EH, Le Poupon C, Briand L, Pernollet JC, et al. (September 2008). "Relationships between molecular structure and perceived odor quality of ligands for a human olfactory receptor". Chemical Senses. 33 (7): 639–53. doi:10.1093/chemse/bjn032. PMID 18603653.

Further reading

• Gaudin JC, Breuils L, Haertlé T (November 2001). "New GPCRs from a human lingual cDNA library". Chemical Senses. 26 (9): 1157–66. doi:10.1093/chemse/26.9.1157. PMID 11705801.
• Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, et al. (September 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR5P3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.