Nucleoporin 93

NUP93
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IJN, 5IJO
Identifiers
Aliases	NUP93, NIC96, NPHS12, nucleoporin 93kDa, nucleoporin 93
External IDs	OMIM: 614351; MGI: 1919055; HomoloGene: 40971; GeneCards: NUP93; OMA:NUP93 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q13 Start 56,730,118 bp[1] End 56,850,286 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C5 Start 94,941,192 bp[2] End 95,043,855 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence left lobe of thyroid gland gonad right lobe of thyroid gland right testis left testis testicle oocyte granulocyte Top expressed in somite zygote yolk sac mandibular prominence primitive streak epiblast maxillary prominence abdominal wall secondary oocyte tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of nuclear pore protein binding Cellular component nuclear membrane membrane nuclear periphery nuclear pore nucleus nuclear envelope host cell Biological process mRNA transport viral transcription protein sumoylation mitotic nuclear membrane disassembly regulation of cellular response to heat protein transport viral process intracellular transport of virus nuclear pore complex assembly negative regulation of hydrogen peroxide-induced cell death tRNA export from nucleus glomerular visceral epithelial cell migration nuclear envelope organization mRNA export from nucleus renal system development positive regulation of SMAD protein signal transduction SMAD protein signal transduction glomerular visceral epithelial cell development regulation of gene silencing by miRNA poly(A)+ mRNA export from nucleus regulation of glycolytic process transport protein import into nucleus nucleocytoplasmic transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9688 71805 Ensembl ENSG00000102900 ENSMUSG00000032939 UniProt Q8N1F7 Q8BJ71 RefSeq (mRNA) NM_001242795 NM_001242796 NM_014669 NM_172410 NM_001357266 NM_001357267 NM_001357268 RefSeq (protein) NP_001229724 NP_001229725 NP_055484 NP_765998 NP_001344195 NP_001344196 NP_001344197 Location (UCSC) Chr 16: 56.73 – 56.85 Mb Chr 8: 94.94 – 95.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nucleoporin 93 (Nup93) is a protein that in humans is encoded by the NUP93 gene.^[5][6][7]

References

1. GRCh38: Ensembl release 89: ENSG00000102900 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032939 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Grandi P, Dang T, Pane N, Shevchenko A, Mann M, Forbes D, Hurt E (Dec 1997). "Nup93, a Vertebrate Homologue of Yeast Nic96p, Forms a Complex with a Novel 205-kDa Protein and Is Required for Correct Nuclear Pore Assembly". Mol Biol Cell. 8 (10): 2017–38. doi:10.1091/mbc.8.10.2017. PMC 25664. PMID 9348540.
6. Shah S, Tugendreich S, Forbes D (May 1998). "Major Binding Sites for the Nuclear Import Receptor Are the Internal Nucleoporin Nup153 and the Adjacent Nuclear Filament Protein Tpr". J Cell Biol. 141 (1): 31–49. doi:10.1083/jcb.141.1.31. PMC 2132719. PMID 9531546.
7. "Entrez Gene: NUP93 nucleoporin 93kDa".

Further reading

• Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Patre M, Tabbert A, Hermann D, et al. (2006). "Caspases target only two architectural components within the core structure of the nuclear pore complex". J. Biol. Chem. 281 (2): 1296–304. doi:10.1074/jbc.M511717200. hdl:11858/00-001M-0000-0028-3A8A-9. PMID 16286466.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Nuclear pore complex protein Nup93