Highway 106 begins at a trumpet interchange with Highway 104.
The route bypasses to the west side of New Glasgow by running along the centre of Abercrombie Point.[3]
It crosses Pictou Harbour to the town of Pictou using the Harvey A. Veniot Causeway, which opened in 1968.[4]
A traffic circle at the west end of Pictou, known as the Pictou Rotary, connects Highway 106 with the centre of town as well as Trunk 6 (the Sunrise Trail) and Route 376. The route is a super two expressway except for a short section of at-grade two lane highway near the northern terminus. The route ends in Caribou at the Northumberland Ferries terminal to Prince Edward Island, where the Trans-Canada Highway designation continues as Prince Edward Island Highway 1.[3]
^ abDepartment of Transportation and Infrastructure Renewal. Primary Traffic Volume Book, 2003–2010(PDF) (Report). Province of Nova Scotia. pp. 155–156. Archived from the original(PDF) on December 20, 2013. Retrieved December 19, 2013.