Ni made her debut in Zhang Yimou's war film The Flowers of War, playing the lead female character "Yu Mo".[3] She received acclaim for her performance in the film and rose to fame.[4]
In 2018, Ni starred in her first television drama, The Rise of Phoenixes alongside Chen Kun. She released her first single, "Why to No Avail" as part of the soundtrack of the series.[15][16]Forbes China listed Ni under their 30 Under 30 Asia 2017 list which consisted of 30 influential people under 30 years old who have had a substantial effect in their fields.[17]
In 2019, Ni returned to the big screen in the crime heist film Savage.[18] She then made her theater debut in the play One One Zero Eight directed by Stan Lai.[19] The same year, Ni starred in the fantasy romance drama Love and Destiny alongside Chang Chen.[20] The series received positive reviews, and Ni gained acclaim for her portrayal of a fairy maiden that went through numerous struggles to attain happiness.[21]
In 2021, Ni starred in romantic-drama film Yanagawa, directed by Korean-Chinese filmmaker Zhang Lü. For her highly praised performance in this film, she was nominated for Best Actress at the 35th Golden Rooster Awards.[24] In the same year, Ni was cast in the drama Night Wanderer, adapted from the popular time-travel themed novel "Ye Lv Ren" (夜旅人) by Zhao Xi Zhi alongside Deng Lun.[25]
In 2014, she was selected to be the brand ambassador for Uniqlo in China,[36] and became a global spokesperson for Uniqlo since 2019.[37]
She was the official global ambassador of Tiffany & Co. between 2017 and 2019.[38][39]
Ni has been the official brand ambassador of Gucci since 2017[40] and a global ambassador for Gucci's Eyewear since 2019.[41] Since 2022, she has been announced as Global Brand Ambassador of Gucci.[42] She became the global face of Gucci Eyewear through various collections' campaigns such as Spring Summer 2017,[43] Fall Winter 2017,[44] Spring Summer 2018,[45] Fall Winter 2018,[46] Sprring Summer 2019,[47] Fall Winter 2019,[48] Spring Summer 2020,[49] Spring Summer 2021,[50] Fall Winter 2021,[51] Spring Summer 2022,[52] Fall Winter 2022,[53] Spring Summer 2023,[54] Fall Winter 2023 [55] and Spring Summer 2024.[56] In January 2020, she became the global face of the Gucci's Chinese New Year with Mickey Mouse-themed collection campaign along with Earl Cave and Zoë Bleu that shot by American photographer and director Harmony Korine.[57] In January 2024, Ni starred as the global face of the Gucci's Valigeria campaign for the Savoy collection along with her co-star in the TV series Love and Destiny - Chang Chen.[58][59][60] In October 2024, Ni starred as the global face of the Gucci's Holiday 2024 campaign "Gucci Gift: Stories from The Savoy" alongside Kendall Jenner, Jessica Chastain and Danielle Pizzorni.[61] In January 2025, Ni starred as the global face of the Gucci's Chinese New Year 2025 campaign "Year of the Snake" alongside Xiao Zhan.[62][63]
Since 2022, French luxury beauty house Lancôme announced Ni as their Global Skincare and Fragrance Ambassador.[67][68] In August 25, 2024, Lancôme announced that Ni was appointed a new role as Global Spokesperson for the brand.[69]
^"倪妮帶隊宣傳35億票房新片 朱一龍首次訪港Nice爆" [Ni Ni leads the team to promote the new movie with a box office of 3.5 billion. Zhu Yilong visits Hong Kong for the first time. Nice explodes] (in Chinese). HongKong On.CC. 21 August 2023. Archived from the original on 3 September 2023. Retrieved 3 September 2023.
^"消失的她" (in Chinese). Maoyan. Retrieved 3 September 2023.
^"第十八届中国长春电影节闭幕 "金鹿奖"十大奖项揭晓" [The 18th China Changchun Film Festival concluded and the top ten "Golden Deer Awards" were announced] (in Chinese). China News. 3 September 2023. Archived from the original on 3 September 2023. Retrieved 3 September 2023.
^"倪妮成为Tiffany蒂芙尼首个中国区品牌代言人" [Ni Ni becomes Tiffany’s first brand spokesperson in China]. KK News (in Chinese). 22 November 2017. Archived from the original on 12 March 2024. Retrieved 12 March 2024.
^"倪妮成為Cindy Chao The Art Jewel全球品牌大使,稀世粉紅鑽流轉優雅形象" [Ni Ni becomes the global brand ambassador of Cindy Chao The Art Jewel, and the rare pink diamond conveys an elegant image]. Tatler Asia. 23 April 2021. Archived from the original on 21 September 2023. Retrieved 21 September 2023.
^"倪妮获得兰蔻全球代言" [Ni Ni wins Lancôme global endorsement] (in Chinese). Madisonboom. 21 September 2022. Archived from the original on 21 September 2023. Retrieved 21 September 2023.
^"倪妮成为兰蔻全球代言人,揭示美妆行业新风潮" [Ni Ni becomes Lancôme's global spokesperson, revealing a new trend in the beauty industry] (in Chinese). Sohu. 25 August 2024. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
^"欧莱雅美发携手倪妮为你解决油头烦恼" [L'Oreal Hairdressing and Ni Ni join hands to solve your oily hair worries] (in Chinese). SocialBeta. 29 July 2022. Archived from the original on 27 February 2024. Retrieved 27 February 2024.
^"凡士林宣布倪妮为亚太区品牌代言人" [Vaseline announces Ni Ni as brand spokesperson in Asia Pacific] (in Chinese). Ganhuoku China. 22 February 2024. Archived from the original on 27 February 2024. Retrieved 27 February 2024.
^"《消失的她》今日震撼上映 八大看点揭秘年度极致悬疑力作" ["The Disappeared Her" is released today in a shocking release. Eight highlights reveal the ultimate suspenseful masterpiece of the year.]. Beijing Youth Net Entertainment (in Chinese). 22 June 2023. Retrieved 3 September 2023.
^"管虎《一个男人和一个女人》立项 黄渤倪妮出演!" [Guan Hu's "A Man and a Woman" project is approved and Huang Bo and Ni Ni will star in it!]. QQ News (in Chinese). 17 April 2024. Retrieved 2 June 2024.
^"上海国际电影节|金爵奖:各国高品质新作集聚主竞赛" [Shanghai International Film Festival|Golden Goblet Award: Main Competition for High-Quality New Works from Various Countries]. The Paper (in Chinese). 31 May 2024. Archived from the original on 2 June 2024. Retrieved 2 June 2024.
^"电影《捆绑上天堂》入围圣塞巴斯蒂安国际电影节主竞赛单元" [The film "Bound to Heaven" was shortlisted for the main competition unit of the San Sebastian International Film Festival]. Mopyule (in Chinese). 30 July 2024. Archived from the original on 30 July 2024. Retrieved 30 July 2024.
^"第十二届华语电影传媒大奖5月海口举行 提名出炉" [The 12th Chinese Film Media Awards will be held in Haikou in May and nominations are announced] (in Chinese). 海口网. 10 April 2012. Archived from the original on 23 August 2019.
^"第15届中国电影华表奖提名名单" [Nomination list for the 15th China Film Huabiao Awards]. China Film Administration. 5 September 2019. Archived from the original on 27 April 2024.
^"第13届澳门国际电影节提名名单公布,《长津湖》5项提名领跑" [The 13th Macau International Film Festival nomination list announced, "Changjin Lake" leads the way with 5 nominations]. QQ News (in Chinese). 9 December 2021. Archived from the original on 4 September 2023.
^"第13届澳门国际电影节提名,倪妮、袁泉女一号竟提名女配角" [Nominated for the 13th Macau International Film Festival, Ni Ni and Yuan Quan Nominated for Supporting Actress]. 163.com (in Chinese). 9 December 2021. Archived from the original on 4 September 2023.
^"第35届金鸡奖提名出炉 沈腾朱一龙易烊千玺等入围". Sina Ent. (in Chinese). 1 November 2022. Archived from the original on 1 November 2022. Retrieved 1 November 2022.
^"2020-2022年度导协表彰大会初评入围名单揭晓" [The preliminary list of finalists for the 2020-2022 Directors Association Commendation Conference has been announced] (in Chinese). China Film Director's Guild. 16 December 2023. Archived from the original on 2 June 2024 – via Beijing News.
^"新华快报 - 倪妮获第十八届中国长春电影节金鹿奖最佳女演员奖" [Xinhua Express - Ni Ni won the Golden Deer Award for Best Actress at the 18th China Changchun Film Festival]. Xinhuanet (in Chinese). 2 September 2023. Archived from the original on 2 September 2023. Retrieved 2 September 2023.
^""龙江制造"电影《余下都是春天》获第15届澳门国际电影节"金莲花"最佳影片奖提名" ["Made in Longjiang" film "The Rest Is Spring" was nominated for the "Golden Lotus" Best Film Award at the 15th Macau International Film Festival] (in Chinese). The Paper China. 6 December 2023. Archived from the original on 8 December 2023. Retrieved 8 December 2023.
^"官宣!第37届大众电影百花奖公布提名名单及主视觉" [Official announcement! The 37th Popular Film Hundred Flowers Awards announced the nomination list and key visual]. Sohu (in Chinese). 2 July 2024. Archived from the original on 2 July 2024.