Use of air ionisers as an experimental non-pharmaceutical treatment
Negative air ionization therapy (NAIs) uses air ionisers as a non-pharmaceutical treatment for respiratory disease, allergy, or stress-related health conditions. The mainstream scientific community considers many applications of NAIs to be pseudoscience.[1][2][3][4][5][6] Many negative ion products release ozone, a chemical known to cause lung damage.[7]
Research
For Seasonal Affective Disorder (SAD), a randomized controlled trial (RCT) comparing high (4.5x1014 ions/second) and low (1.7x1011 ions/second) flow rate negative air ionization with bright light therapy found that the post-treatment improvement percentage was 57.1% for bright light, 47.9% for high-density ions and 22.7% for low-density ions.[8] An older RCT conducted by the same authors also found air ionization effective for SAD.[9] A 2007 review considers this therapy "under investigation" and suggests that it may be a helpful treatment for SAD.[10]
An RCT comparing the short-term effects of bright light, an auditory stimulus, and high and low-density negative ions on mood and alertness in mildly depressed and non-depressed adults found that the three first (active) stimuli, but not the low-density placebo, reduced depression on the Beck Depression Inventory scale.[citation needed] The auditory stimulus, bright light, and high-density ions all produced rapid mood changes - with small to medium effect sizes - in depressed and non-depressed subjects.[11]
Researchers have continued to cite a dearth of evidence about the effects of negative air ionization. "The presence of NAIs is credited for increasing psychological health, productivity, and overall well-being but without consistent or reliable evidence in therapeutic effects and with controversy in anti-microorganisms," researchers wrote in a 2018 article published in the International Journal of Molecular Sciences.[5]
^Terman, M.; Terman, J. S. (2006). "Controlled Trial of Naturalistic Dawn Simulation and Negative Air Ionization for Seasonal Affective Disorder". American Journal of Psychiatry. 163 (12): 2126–33. doi:10.1176/appi.ajp.163.12.2126. PMID17151164.
^Westrin, ÅS.; Lam, R. (2007). "Seasonal Affective Disorder: A Clinical Update". Annals of Clinical Psychiatry. 19 (4): 239–46. doi:10.1080/10401230701653476. PMID18058281.
^Goel, N.; Etwaroo, G. R. (2006). "Bright light, negative air ions and auditory stimuli produce rapid mood changes in a student population: a placebo-controlled study". Psychological Medicine. 36 (9): 1253–63. doi:10.1017/S0033291706008002. PMID16756690. S2CID22291389.
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