Germani's is well known as a soap opera actress, having starred in Deň a Noc (2013), Dr. Ema (2014), Divoké Kone (2015), Panelák (2017), Alica (2018), Hranica (2022) and Iveta (2023).[5][6]
Germani is also active as a stage actress, regularly appearing in plays of the GUnaGU theatre as well as the Slovak National Theatre.[7]
Germani debuted as a movie actress in 2018, in the main role of the Czech movie Večne tvoja neverná.[8] Her first main role was in the 2019 Czech drama Amnesty.
In 2023 she played the Czech Olympic diver turned pornographic actress Andrea Absolonová in the movie The Body.[9]
In 2015 she changed her name to Natalia Germani, to make it more accessible for international audiences.[7] In 2023 she was included in the 30 under 30 list by the Slovak edition of Forbes.[8]
Germani is married to the musician Martin Valihora. They have two daughters.[3]