Dean was invited to the 2022 NFL Scouting Combine. He performed limited positional drills due to an injury (a torn pectoral muscle) that he suffered while training for the NFL Draft.[8]
Dean was selected in the third round (83rd overall) of the 2022 NFL Draft by the Philadelphia Eagles.[12] His draft-day slide was considered surprising, but NFL analyst Ian Rapoport pointed out that teams were reportedly concerned about Dean's size, and his decision to opt against getting surgery to repair his pectoral injury. Dean appeared in all 17 games as a rookie and mainly played on special teams.[13] Dean's rookie season ended with a trip to Super Bowl LVII where the Eagles lost 38–35 to the Kansas City Chiefs.[14]
Dean entered the 2023 season as the Eagles starting middle linebacker. He suffered a foot injury in Week 1 and was placed on injured reserve on September 12, 2023.[15] He was activated on October 14, but placed back on injured reserve on November 16 with a Lisfranc injury.[16]
On November 3, 2024, during a Week 9 matchup against the Jacksonville Jaguars, Dean recorded his first career interception to effectively win the game, 28–23.[17]
Personal life
Dean is a member of Omega Psi Phi fraternity and was initiated while at Georgia.
Dean's older brother, Nikolas, played tight end at Ole Miss.[18] In 2022, Dean was named the Arthur Ashe Jr. Male Sports Scholar of the Year by Diverse: Issues In Higher Education.[19]