NXPH1

NXPH1
Identifiers
Aliases	NXPH1, NPH1, Nbla00697, neurexophilin 1
External IDs	OMIM: 604639; MGI: 107492; GeneCards: NXPH1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	8,752,961 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	9,249,032 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; endothelial cell; ; secondary oocyte; ; prefrontal cortex; ; testicle; ; left adrenal gland; ; left adrenal cortex; ; hypothalamus; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	lateral septal nucleus; ; medial dorsal nucleus; ; dorsomedial hypothalamic nucleus; ; ventral tegmental area; ; anterior amygdaloid area; ; dorsal tegmental nucleus; ; medial vestibular nucleus; ; habenula; ; lumbar subsegment of spinal cord; ; ventromedial nucleus;
	More reference expression data
	More reference expression data
Orthologs
Databases	NCBI: entry; OMA: entry
	30010
	18231
	ENSG00000122584
	ENSMUSG00000046178
	P58417
	Q61200
	NM_152745
	NM_008751
	NP_689958
	NP_032777
	Wikidata
View/Edit Human	View/Edit Mouse

Neurexophilin-1 is a protein that in humans is encoded by the NXPH1 gene.^[5]^[6]

This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122584 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046178 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Missler M, Sudhof TC (Jun 1998). "Neurexophilins form a conserved family of neuropeptide-like glycoproteins". J Neurosci. 18 (10): 3630–8. doi:10.1523/JNEUROSCI.18-10-03630.1998. PMC 6793134. PMID 9570794.
^ ^a ^b "Entrez Gene: NXPH1 neurexophilin 1".

Ohira M, Morohashi A, Nakamura Y, et al. (2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma". Cancer Lett. 197 (1–2): 63–68. doi:10.1016/S0304-3835(03)00085-5. PMID 12880961.
Petrenko AG, Ullrich B, Missler M, et al. (1996). "Structure and evolution of neurexophilin". J. Neurosci. 16 (14): 4360–9. doi:10.1523/JNEUROSCI.16-14-04360.1996. PMC 6578849. PMID 8699246.
Missler M, Hammer RE, Südhof TC (1999). "Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit". J. Biol. Chem. 273 (52): 34716–34723. doi:10.1074/jbc.273.52.34716. PMID 9856994.
Clarris HJ, McKeown S, Key B (2003). "Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb". Int. J. Dev. Biol. 46 (4): 649–52. PMID 12141453.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–164. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122584 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046178 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9570794-5] Missler M, Sudhof TC (Jun 1998). "Neurexophilins form a conserved family of neuropeptide-like glycoproteins". J Neurosci. 18 (10): 3630–8. doi:10.1523/JNEUROSCI.18-10-03630.1998. PMC 6793134. PMID 9570794.

[entrez-6] "Entrez Gene: NXPH1 neurexophilin 1".

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NXPH1

References

Further reading

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