Nucleotide-binding protein 2 (NBP 2) also known as cytosolic Fe-S cluster assembly factor NUBP2 is a protein that in humans is encoded by the NUBP2gene.[5]
NUBP2 is a member of the NUBP/MRP gene subfamily of ATP-binding proteins.[6] There are two types in eukaryotesNUBP1 and NUBP2, and one novel human gene that define NBP nucleotide-binding proteins (NUBP/MRP-multidrug resistance-associated protein)[5] in mammalian cells requires the maturation of cytosolic[7] iron-sulfur (Fe/S)[8] proteins as Nubp1 is involved in the formation of extramitochondrial Fe/S proteins[6] the cell division inhibitor MinD is homologous[9] and involve two proteins components of the (FeS) protein assembly machinery closely similar cytosolic[6] soluble[8]P loop[9]NTPase where Nar1[10][11] is required for assembly,[12] identified Cfd1p[13][14] in cytosolic and nuclear Fe/S protein biogenesis[8] in yeast.[15] Nubp proteins NTPase Nbp35p.[11][12]MinD is homologous to members in MinD of E. coli, a relative of the ParA family.[9][16][17]
NBP35 bacterial plasmids F (the classical Escherichia coli sex factor)[9] is found in all nuclear genes in vegetative and gametic flagella of the unicellular green algae C. reinhardtii and nuclear Fe/S protein biogenesis required for cytosolic iron-sulfur protein assembly; MNP =MRP-like; MRP (Multiple Resistance and pH adaptation) MRP/NBP35-like P-loop NTPase similar to; and functions as minD_arch; cell division ATPase MinD, archaeal and homologue's of NUBP1. The NBP35 gene is conserved in archaea[18] Bacteria, Metazoa, Fungi and other Eukaryotes and with considerable divergence from the yeast; Cfd1-Nbp35 Fe-S to man. In a scaffold complex[19] protein to form large molecular assemblies that store Fe(III) and 4Fe-4S seen as secondary to defects inactivated to accomplish its functions as physiologically relevant form(s) Fe/S proteins Iron regulatory protein 1 (IRP1) is regulated through[14] prevents deficiencies and increased mutation rates[17] that characterized a plant P loop NTPase with sequence similarity to Nbp35 homologue's of NUBP1.[20]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abNakashima H, Grahovac MJ, Mazzarella R, et al. (1999). "Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome 17, and Nubp1, mapped to chromosome 16--establish a new gene family of nucleotide-binding proteins in eukaryotes". Genomics. 60 (2): 152–60. doi:10.1006/geno.1999.5898. PMID10486206.
^Netz DJ, Pierik AJ, Stümpfig M, Mühlenhoff U, Lill R (2007). "The Cfd1-Nbp35 complex acts as a scaffold for iron-sulfur protein assembly in the yeast cytosol". Nat Chem Biol. 3 (5): 278–86. doi:10.1038/nchembio872. PMID17401378.
^Kohbushi H, Nakai Y, Kikuchi S, Yabe T, Hori H, Nakai M (2009). "Arabidopsis cytosolic Nbp35 homodimer can assemble both [2Fe-2S] and [4Fe-4S] clusters in two distinct domains". Biochem Biophys Res Commun. 378 (4): 810–5. doi:10.1016/j.bbrc.2008.11.138. PMID19084504.
^Christodoulou A, Lederer CW, Surrey T, Vernos I, Santama N (2006). "Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication". J Cell Sci. 119 (Pt 10): 2035–47. doi:10.1242/jcs.02922. PMID16638812. S2CID1004740.
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