NRD1

NRDC
Identifiers
Aliases	NRDC, hNRD1, hNRD2, NRD1, nardilysin convertase, nardilysin
External IDs	OMIM: 602651; MGI: 1201386; GeneCards: NRDC
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	51,878,805 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	108,918,974 bp
RNA expression pattern
	Top expressed in
	glutes; ; right testis; ; left testis; ; muscle of thigh; ; triceps brachii muscle; ; gastrocnemius muscle; ; anterior pituitary; ; sperm; ; Skeletal muscle tissue of biceps brachii; ; thoracic diaphragm;
	Top expressed in
	seminiferous tubule; ; tail of embryo; ; genital tubercle; ; granulocyte; ; spermatid; ; plantaris muscle; ; neural layer of retina; ; muscle of thigh; ; extensor digitorum longus muscle; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; protein binding; catalytic activity; metallopeptidase activity; hydrolase activity; metal ion binding; epidermal growth factor binding; metalloendopeptidase activity;
Cellular component	cell surface; cytosol; mitochondrion;
Biological process	positive regulation of membrane protein ectodomain proteolysis; cell population proliferation; neuromuscular junction development; cell migration; regulation of endopeptidase activity; proteolysis; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	4898
	230598
	ENSG00000078618
	ENSMUSG00000053510
	O43847
	Q8BHG1
	NM_001101662; NM_001242361; NM_002525
	NM_146150; NM_001346554; NM_001347169
	NP_001095132; NP_001229290; NP_002516
	NP_001333483; NP_001334098; NP_666262
	Wikidata
View/Edit Human	View/Edit Mouse

Nardilysin is an enzyme that in humans is encoded by the gene NRDC (formally NRD1).^[5]^[6]^[7] Nardilysin is a type of protease, which means it functions to cut the bonds between certain amino acids. More specifically, it’s an endopeptidase that cleaves bonds at the N-terminus of arginine residues connected to other basic amino acids.^[7] This activity also explains its alternative name, N-arginine dibasic convertase, hence its standard name.

Interactions

Nardilysin has been shown to interact with Heparin-binding EGF-like growth factor.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078618 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053510 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hospital V, Prat A, Joulie C, Cherif D, Day R, Cohen P (May 1998). "Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family". Biochem J. 327 (3): 773–9. doi:10.1042/bj3270773. PMC 1218856. PMID 9581555.
^ Fumagalli P, Accarino M, Egeo A, Scartezzini P, Rappazzo G, Pizzuti A, Avvantaggiato V, Simeone A, Arrigo G, Zuffardi O, Ottolenghi S, Taramelli R (Apr 1998). "Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues". Genomics. 47 (2): 238–45. doi:10.1006/geno.1997.5078. PMID 9479496.
^ ^a ^b "Entrez Gene: NRD1 nardilysin (N-arginine dibasic convertase)".
^ Nishi, E; Prat A; Hospital V; Elenius K; Klagsbrun M (Jul 2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration". EMBO J. 20 (13). England: 3342–50. doi:10.1093/emboj/20.13.3342. ISSN 0261-4189. PMC 125525. PMID 11432822.

Seidah NG, Prat A (2003). "Precursor convertases in the secretory pathway, cytosol and extracellular milieu". Essays Biochem. 38: 79–94. doi:10.1042/bse0380079. PMID 12463163.
Hospital V, Prat A (2005). "Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation". Protein Pept. Lett. 11 (5): 501–8. doi:10.2174/0929866043406508. PMID 15544571.
Winter AG, Pierotti AR (2001). "Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines". Biochem. J. 351 (3): 755–64. doi:10.1042/0264-6021:3510755. PMC 1221416. PMID 11042131.
Nishi E, Prat A, Hospital V, et al. (2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration". EMBO J. 20 (13): 3342–50. doi:10.1093/emboj/20.13.3342. PMC 125525. PMID 11432822.
Ma Z, Csuhai E, Chow KM, Hersh LB (2001). "Expression of the acidic stretch of nardilysin as a functional binding domain". Biochemistry. 40 (31): 9447–52. doi:10.1021/bi010538x. PMID 11478915.
Hospital V, Nishi E, Klagsbrun M, et al. (2003). "The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF)". Biochem. J. 367 (Pt 1): 229–38. doi:10.1042/BJ20020822. PMC 1222870. PMID 12095415.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chow KM, Oakley O, Goodman J, et al. (2003). "Nardilysin cleaves peptides at monobasic sites". Biochemistry. 42 (7): 2239–44. doi:10.1021/bi027178d. PMID 12590613.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Nishi E, Hiraoka Y, Yoshida K, et al. (2006). "Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme". J. Biol. Chem. 281 (41): 31164–72. doi:10.1074/jbc.M601316200. PMID 16923819.
Bernstein HG, Stricker R, Dobrowolny H, et al. (2007). "Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons". Neuroscience. 146 (4): 1513–23. doi:10.1016/j.neuroscience.2007.02.057. PMID 17442499. S2CID 8060302.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000078618 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053510 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9581555-5] Hospital V, Prat A, Joulie C, Cherif D, Day R, Cohen P (May 1998). "Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family". Biochem J. 327 (3): 773–9. doi:10.1042/bj3270773. PMC 1218856. PMID 9581555.

[pmid9479496-6] Fumagalli P, Accarino M, Egeo A, Scartezzini P, Rappazzo G, Pizzuti A, Avvantaggiato V, Simeone A, Arrigo G, Zuffardi O, Ottolenghi S, Taramelli R (Apr 1998). "Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues". Genomics. 47 (2): 238–45. doi:10.1006/geno.1997.5078. PMID 9479496.

[entrez-7] "Entrez Gene: NRD1 nardilysin (N-arginine dibasic convertase)".

[pmid11432822-8] Nishi, E; Prat A; Hospital V; Elenius K; Klagsbrun M (Jul 2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration". EMBO J. 20 (13). England: 3342–50. doi:10.1093/emboj/20.13.3342. ISSN 0261-4189. PMC 125525. PMID 11432822.

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NRD1

Interactions

See also

References

Further reading

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