NPTXR

NPTXR
Identifiers
Aliases	NPTXR, NPR, neuronal pentraxin receptor
External IDs	OMIM: 609474; MGI: 1920590; GeneCards: NPTXR
Gene location (Human)
Chr.	Chromosome 22 (human)
End	38,844,028 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	79,688,967 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; frontal pole; ; Region I of hippocampus proper; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; dorsolateral prefrontal cortex; ; amygdala; ; Brodmann area 9; ; orbitofrontal cortex;
	Top expressed in
	piriform cortex; ; subiculum; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; anterior amygdaloid area; ; superior frontal gyrus; ; habenula; ; primary motor cortex; ; cingulate gyrus; ; medial dorsal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding;
Cellular component	membrane; integral component of membrane; plasma membrane; cytoplasmic side of plasma membrane; filopodium; dendrite; growth cone; soma; glutamatergic synapse;
Biological process	neuron projection development; regulation of postsynaptic neurotransmitter receptor activity;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23467
	73340
	ENSG00000221890
	ENSMUSG00000022421
	O95502
	Q99J85
	NM_058178; NM_014293
	NM_030689
	NP_055108
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal pentraxin receptor is a protein that in humans is encoded by the NPTXR gene.^[5]^[6]

This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat protein pentraxin is thought to mediate neuronal uptake of synaptic material and the presynaptic snake venom toxin, taipoxin. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for human and mouse, based on strong sequence conservation amongst these species.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000221890 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022421 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Andersson KB, Florholmen G, Winer LH, Tonnessen T, Christensen G (Feb 2006). "Regulation of neuronal type genes in congestive heart failure rats". Acta Physiol (Oxf). 186 (1): 17–27. doi:10.1111/j.1748-1716.2005.01503.x. PMID 16497176. S2CID 46217094.
^ ^a ^b "Entrez Gene: NPTXR neuronal pentraxin receptor".

Poulsen TT, Pedersen N, Perin MS, et al. (2006). "Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin". Lung Cancer. 50 (3): 329–37. doi:10.1016/j.lungcan.2005.06.011. PMID 16115696.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS (2000). "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2". J. Biol. Chem. 275 (23): 17786–92. doi:10.1074/jbc.M002254200. PMID 10748068.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Dodds DC, Omeis IA, Cushman SJ, et al. (1997). "Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49". J. Biol. Chem. 272 (34): 21488–94. doi:10.1074/jbc.272.34.21488. PMID 9261167.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000221890 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022421 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16497176-5] Andersson KB, Florholmen G, Winer LH, Tonnessen T, Christensen G (Feb 2006). "Regulation of neuronal type genes in congestive heart failure rats". Acta Physiol (Oxf). 186 (1): 17–27. doi:10.1111/j.1748-1716.2005.01503.x. PMID 16497176. S2CID 46217094.

[entrez-6] "Entrez Gene: NPTXR neuronal pentraxin receptor".

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[5]

[6]

NPTXR

See also

References

Further reading

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