NFRKB

3U21, 4UF6, 4WLP

NFRKB

Identifiers

NFRKB, INO80G, nuclear factor related to kappaB binding protein

External IDs

OMIM: 164013; MGI: 2442410; GeneCards: NFRKB

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3U21, 4UF6, 4WLP

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q24.3	Start	129,863,636 bp^[1]
Band	11q24.3	End	129,895,590 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 A4	Start	31,297,488 bp^[2]
Band	9\|9 A4	End	31,332,629 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

buccal mucosa cell

secondary oocyte

testicle

endothelial cell

left lobe of thyroid gland

right uterine tube

right lobe of thyroid gland

gonad

skin of leg

left ovary

Top expressed in

secondary oocyte

superior cervical ganglion

primary oocyte

hand

otolith organ

zygote

utricle

medullary collecting duct

spermatocyte

thymus

More reference expression data


More reference expression data

Gene ontology
Molecular function	protease binding DNA binding protein binding
Cellular component	nucleus Ino80 complex nucleoplasm
Biological process	DNA recombination inflammatory response regulation of transcription, DNA-templated transcription by RNA polymerase II DNA repair transcription, DNA-templated cellular response to DNA damage stimulus protein deubiquitination
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


4798


235134


ENSG00000170322


ENSMUSG00000042185


Q6P4R8


Q6PIJ4

RefSeq (mRNA)


NM_001143835 NM_006165


NM_172766 NM_001359654

RefSeq (protein)


NP_001137307 NP_006156 NP_001137307.1

NP_766354 NP_001346583 NP_001392026 NP_001392027 NP_001392028
NP_001392030 NP_001392031

Location (UCSC)

Chr 11: 129.86 – 129.9 Mb

Chr 9: 31.3 – 31.33 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Nuclear factor related to kappa-B-binding protein is a protein that in humans is encoded by the NFRKB gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170322 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042185 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Adams BS, Leung K, Meltzer PS, Lewis KA, Wagner-McPherson C, Evans GA, Nabel GJ (Dec 1992). "Localization of the gene encoding R kappa B (NFRKB), a tissue-specific DNA binding protein, to chromosome 11q24-q25" (PDF). Genomics. 14 (2): 270–4. doi:10.1016/S0888-7543(05)80216-2. hdl:2027.42/29810. PMID 1427843.
^ "Entrez Gene: NFRKB nuclear factor related to kappaB binding protein".

Further reading

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Urban MB, Schreck R, Baeuerle PA (1991). "NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit". EMBO J. 10 (7): 1817–25. doi:10.1002/j.1460-2075.1991.tb07707.x. PMC 452856. PMID 2050119.
Adams BS, Leung KY, Hanley EW, Nabel GJ (1992). "Cloning of R kappa B, a novel DNA-binding protein that recognizes the interleukin-2 receptor alpha chain kappa B site". New Biol. 3 (11): 1063–73. PMID 1777480.

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