Medronic acid

Not to be confused with mildronate or minodronate.

Medronic acid

Names
Preferred IUPAC name Methylenebis(phosphonic acid)
Other names methanediphosphonic acid; methylene diphosphonate; medronate; phosphonomethylphosphonic acid; MDP
Identifiers
CAS Number	1984-15-2^N
3D model (JSmol)	Interactive image
ChEBI	CHEBI:43945^N
ChEMBL	ChEMBL180570^Y
ChemSpider	15308^Y
ECHA InfoCard	100.016.229
KEGG	D04887^Y
PubChem CID	16124
UNII	73OS0QIN3O^N
CompTox Dashboard (EPA)	DTXSID8045696
InChI InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7)^Y Key: MBKDYNNUVRNNRF-UHFFFAOYSA-N^Y
SMILES O=P(O)(O)CP(=O)(O)O
Properties
Chemical formula	CH6O6P2
Molar mass	176.001 g·mol^−1
Melting point	199 to 200 °C (390 to 392 °F; 472 to 473 K)[1]
Hazards
Lethal dose or concentration (LD, LC):
LD50 (median dose)	45-50 mg/kg (i.v., mice, rabbits)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references

Medronic acid (conjugate base, medronate), also known as methylene diphosphonate, is the smallest bisphosphonate. Its complex with radioactive technetium, ^99mTc medronic acid, is used in nuclear medicine to detect bone abnormalities, including metastases.

References

1. Budavari, Susan, ed. (1996), The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (12th ed.), Merck, ISBN 0911910123

External links