Sereni was born in Foligno in 1960 to Joseph and Ines Sereni, both of whom worked on the railways. She graduated from the "Federico Frezzi Foligno" School and then moved to Perugia. She did not attend any university course.[1]
In the 2001 elections, Sereni was elected to the Chamber of Deputies in the single-member constituency of Foligno, for the center-left coalition. Since December 2001, she has been a member of the national secretariat of the DS, at first with foreign law enforcement officer and later as head of the organization.
Sereni was confirmed in 2006 election, a candidate in the constituency in the list of the Olive Tree in Umbria. In the XV Legislature, she served on the Defence Committee and as deputy chair of the Chamber of Deputies. From 23 May 2007, she was one of 45 members of the DS National Committee, which brought together the leaders of the party's future members. Among the constituents of the Democratic Party, elected in the primary elections of October 14, 2007, is now part of the Commission's Statute of PD. She was re-elected to the Chamber in the 2008 election. From 7 November 2009 to 15 December 2013 she was vice president of the Democratic Party, along with Ivan Scalfarotto.
Engagement in the Chamber of Deputies as a candidate of the Democratic Party in the constituency list Umbria in view of the Italian election of 2013 in which she was re-elected deputy. On 21 March 2013 she was elected vice-president of the Chamber of Deputies.[2]
In September 2019, Sereni was appointed deputy minister at the Ministry of Foreign Affairs and International Cooperation, serving under ministerLuigi Di Maio.
