Maria Fisker started playing handball at Vissing-Hadsten HK. In 2005 she signed for Randers HK, but only stayed there for a year before signing for the Danish top club Viborg HK. She debuted for the Viborg team in 2007, 25 days before she turned 17. This made her the third youngest player in the Danish Handball League at the time.[3]
In 2015 she suffered a concussion that put her on the sidelines for the entire spring season. She had just signed for Romanian club CSM București, where she only played for a season.
She returned to Danish handball to join her former club Randers HK in 2016, where she played for 3 years, before re-joining Viborg HK. In 2019 Viborg HK signed her to replace Ann Grete Nørgaard, who had signed for SCM Ramnicu Valcea.[4]
