Griffin was a walk-on at UT in 2003. The 5th year strong safety had a great first year as a starter as he earned UT's Outstanding Defensive Newcomer Award. In all 5 years in college, he had 227 tackles, 6 interceptions and 91 yards.
In 2005, he played in all 13 games for the 2005 Texas Longhorns football team at free safety and on special teams and recorded 32 tackles.
In 2006, he appeared in 11 games for the 2006 Texas Longhorns football team, starting 10, all at strong safety. The two missed games were against Rice and Baylor and were due to injury. He was named a second-team Academic All-Big 12 honoree as well as UT's Outstanding Defensive Newcomer.
Griffin had a great 2007 senior season, in which he led the Longhorns in tackles (99) and interceptions (5).