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Manuel Angelos or Angelus (Greek: Μανουήλ Ἄγγελος) may refer to:

Manuel Angelos (after 1195–1212), son of Isaac II Angelos
Manuel Komnenos Doukas (ca. 1187–ca. 1241), ruler of Thessalonica 1230–1237; Thessaly 1239–1241
Manuel Angelos Philanthropenos, ruler of Thessaly 1390–1393

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