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an important epigenetic regulator of complex behaviors. Rodent models of MLL1 dysfunction in forebrain neurons showed that conditional deletion results...
Click to read more »and degrade noncoding RNAs. Cyp33 in mammals causes isomerization in MLL1. MLL1 is a multiprotein complex that regulates gene expression and chromosomal...
Click to read more »lysines. The COMPASS complex is an example of a trithorax-group protein. The MLL1/SET domain associated with the COMPASS complex have crystal structure. The...
Click to read more »suppressing the activity of the histone methyltransferase MLL1, also known as KMT2A. The inhibition of MLL1 via the small-molecule inhibitor MM-401 in EpiSCs...
Click to read more »part of two histone acetyltransferase complexes: the NSL complex, and the MLL1 complex. The NSL Complex (or Non-Specific Lethal complex), is a multi-protein...
Click to read more »hydrolase activity Cellular component cytoplasm nucleolus nucleus nucleoplasm MLL1 complex Biological process proteolysis rRNA processing protein desumoylation...
Click to read more »family of six Set1-like H3K4 methyltransferases that also contains KMT2A (or MLL1), KMT2B (or MLL2), KMT2C (or MLL3), KMT2F (or SET1A), and KMT2G (or SET1B)...
Click to read more »"Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF". Cell. 121 (6): 873–885. doi:10.1016/j...
Click to read more »histone binding armadillo repeat domain binding Cellular component nucleoplasm MLL1 complex nucleus protein-containing complex Biological process regulation...
Click to read more »that of the TrxG-related H3K4-HMTase MLL1; however, ASH1L's association with chromatin can occur independently of MLL1. While ASH1L binds to the 5'-transcribed...
Click to read more »ontology Molecular function molecular function Cellular component nucleus MLL1 complex Ino80 complex fibrillar center nucleoplasm Biological process regulation...
Click to read more »body nuclear speck U4/U6 x U5 tri-snRNP complex U4atac snRNP nucleoplasm MLL1 complex U2-type spliceosomal complex precatalytic spliceosome spliceosomal...
Click to read more »acetyltransferase complex intracellular anatomical structure nucleoplasm MLL1 complex extracellular exosome nucleus Swr1 complex R2TP complex cytoplasm...
Click to read more »2006). "Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex". Nat. Struct. Mol. Biol. 13 (8): 704–12. doi:10.1038/nsmb1119. PMC 4698793...
Click to read more »component cytoplasm membrane SAGA-type complex Set1C/COMPASS complex axon soma MLL1 complex dendrite histone acetyltransferase complex nucleus nucleoplasm protein-containing...
Click to read more »to bind directly to TAF9: p53, VP16, HSF1, NF-IL6, NFAT1, NF-κB, and ALL1/MLL1. Inside of these 17 amino acids, a unique Nine-amino-acid transactivation...
Click to read more »"Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF". Cell. 121 (6): 873–85. doi:10.1016/j...
Click to read more »Molecular function RNA binding endonuclease activity Cellular component MLL1 complex nucleolus membrane nucleus nucleoplasm cytoplasm preribosome, large...
Click to read more »SASP expression is induced by a number of transcription factors, including MLL1 (KMT2A), C/EBPβ, and NF-κB. NF-κB and the enzyme CD38 are mutually activating...
Click to read more »histone acetyltransferase complex nucleoplasm microtubule organizing center MLL1 complex extracellular exosome cytoskeleton nucleus Swr1 complex R2TP complex...
Click to read more »Cellular component cytoplasm Golgi apparatus transcription factor TFTC complex MLL1 complex cyclin/CDK positive transcription elongation factor complex nucleus...
Click to read more »protein binding RNA binding Cellular component nucleus membrane cytoplasm MLL1 complex nucleoplasm nucleolus Biological process positive regulation of transcription...
Click to read more »Q (March 2021). "Long non-coding RNA ROR recruits histone transmethylase MLL1 to up-regulate TIMP3 expression and promote breast cancer progression". Journal...
Click to read more »H3K4me3Q5his was also found to inhibit the H3K4 methyltransferase activities of MLL1-4 and SETD1A/B complexes, all of which require WDR5 as a co-factor. Taken...
Click to read more »activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm MLL1 complex Biological process regulation of transcription, DNA-templated transcription...
Click to read more »2006). "Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex". Nature Structural & Molecular Biology. 13 (8): 704–12. doi:10.1038/nsmb1119...
Click to read more »heterodimerization activity aryl hydrocarbon receptor binding Cellular component MLL1 complex transcription factor TFTC complex cytosol nucleus nucleoplasm SAGA...
Click to read more »Histone-lysine N-methyltransferase 2A, also known as mixed-lineage leukemia 1 (MLL1), is associated with acute lymphoblastic leukemia. KMT2A–AFF1, or MLL-AFF1...
Click to read more »nuclear membrane histone acetyltransferase complex nucleus nucleoplasm cytosol MLL1 complex Biological process histone H4-K16 acetylation regulation of transcription...
Click to read more »deficient in a particular histone-methyltransferase gene, KMT2A (also known as MLL1), in adult excitatory neurons show impairments in hippocampus-dependent memory...
Click to read more »transcription initiation factor activity Cellular component nucleoplasm MLL1 complex nucleus nucleolus transcription regulator complex transcription factor...
Click to read more »transcription factor TFTC complex transcription factor TFIID complex nucleoplasm MLL1 complex nucleus cytosol protein-containing complex Biological process regulation...
Click to read more »ontology Molecular function protein binding Cellular component cytoplasm MLL1 complex nucleolus nucleus Rix1 complex nucleoplasm Biological process rRNA...
Click to read more »Canaani E, Young RA (June 2005). "Global and Hox-specific roles for the MLL1 methyltransferase". Proceedings of the National Academy of Sciences of the...
Click to read more »cell projection dendrite nucleus nucleoplasm cytoplasm protein-DNA complex MLL1 complex RNA polymerase II transcription regulator complex Biological process...
Click to read more »N-methyltransferase activity DNA binding Cellular component nucleoplasm MLL1 complex MLL3/4 complex nucleus histone methyltransferase complex Set1C/COMPASS...
Click to read more »dendrite cytoplasm polysome perikaryon endoplasmic reticulum Ino80 complex MLL1 complex NSL complex Biological process positive regulation of protein localization...
Click to read more »PMID 21677750. Goveas, Neethu; Waskow, Claudia; Arndt, Katharina; et al. (2021). "MLL1 is required for maintenance of intestinal stem cells". PLOS Genetics. 17...
Click to read more »"Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF". Cell. 121 (6): 873–85. doi:10.1016/j...
Click to read more »"Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF". Cell. 121 (6): 873–85. doi:10.1016/j...
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