MEX3D

MEX3D
Identifiers
Aliases	MEX3D, MEX-3D, MEX3, OK/SW-cl.4, RKHD1, RNF193, TINO, mex-3 RNA binding family member D
External IDs	OMIM: 611009; MGI: 2681847; GeneCards: MEX3D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DGR
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,568,325 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,223,493 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; ganglionic eminence; ; ventricular zone; ; secondary oocyte; ; stromal cell of endometrium; ; C1 segment; ; mucosa of transverse colon; ; sural nerve; ; left ovary;
	Top expressed in
	seminiferous tubule; ; hand; ; medial ganglionic eminence; ; mandibular prominence; ; maxillary prominence; ; superior cervical ganglion; ; spermatid; ; endocardial cushion; ; Gonadal ridge; ; Rostral migratory stream;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; nucleic acid binding; RNA binding; mRNA 3'-UTR AU-rich region binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; nucleus;
Biological process	mRNA destabilization; mRNA localization resulting in posttranscriptional regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	399664
	237400
	ENSG00000181588
	ENSMUSG00000048696
	Q86XN8
	Q3UE17
	NM_001174118; NM_203304
	NM_198615
	NP_001167589; NP_976049
	NP_941017
	Wikidata
View/Edit Human	View/Edit Mouse

Mex-3 homolog D (C. elegans), also known as MEX3D, is a protein that in humans is encoded by the MEX3D gene.^[5]^[6]

Function

MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.^[6]

Structure

MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs (KH domain) and a RING domain at the C-terminus.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181588 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048696 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: mex-3 homolog D (C. elegans)".
^ ^a ^b ^c Donnini M, Lapucci A, Papucci L, Witort E, Jacquier A, Brewer G, Nicolin A, Capaccioli S, Schiavone N (May 2004). "Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein". J. Biol. Chem. 279 (19): 20154–66. doi:10.1074/jbc.M314071200. hdl:2158/356837. PMID 14769789.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Buchet-Poyau K, Courchet J, Le Hir H, et al. (2007). "Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies". Nucleic Acids Res. 35 (4): 1289–300. doi:10.1093/nar/gkm016. PMC 1851655. PMID 17267406.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181588 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048696 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: mex-3 homolog D (C. elegans)".

[pmid14769789-6] Donnini M, Lapucci A, Papucci L, Witort E, Jacquier A, Brewer G, Nicolin A, Capaccioli S, Schiavone N (May 2004). "Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein". J. Biol. Chem. 279 (19): 20154–66. doi:10.1074/jbc.M314071200. hdl:2158/356837. PMID 14769789.

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MEX3D

Function

Structure

References

Further reading

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