On November 24, 2015, Frías signed with the Arizona Diamondbacks as an international free agent.[1]
The Diamondbacks added him to their 40-man roster after the 2020 season.[2] On February 22, 2021, Frías was placed on the reserve/COVID-19 list as he continued to recover from the virus.[3] Frías was called up for his MLB debut on September 19, 2021.[4]
Frías was optioned to the Triple-A Reno Aces to begin the 2023 season.[5]