Linda Randall

Linda Randall is a Professor Emerita of Biochemistry and Wurdack Chair Emerita of Biological Chemistry at the University of Missouri.[1] Her research has shown unexpected and complex details of the movement of newly made proteins from the cytosol across membranes into the organelles of the cell.  In particular, she found that the entire protein was kept unfolded by association with a chaperone and not just directed to cross membranes by its terminal leader sequence.[2] In 1997, she was elected to the National Academy of Sciences of the USA because of the excellence of this work.  She has received a number of other honors and awards.[2]

Education

Randall received her BS from Colorado State University in Zoology and her PhD at the University of Wisconsin in Molecular Biology.[1]

Academic research career

Randall was a professor at the University of Uppsala for eight years before joining the faculty at Washington State University, WSU, in 1981.[3] After twenty years at WSU, she moved to the University of Missouri.[4]

Randall's research focuses on the mechanism of protein export in the bacterium Escherichia coli.[5] Her laboratory demonstrated the role of chaperones in the transport and folding of proteins.[2][5]

Honors and awards

Selected works

  • Bariya P, Randall LL. (2018). “Co-assembly of SecYEG and SecA fully restores the properties of the native translocon.” J Bacteriol. 2018 Oct 1. doi:10.1128 JB.00493-18 Epub ahead of print.
  • Findik BT, Smith VF, Randall LL. (2018). “Penetration into membrane of amino-terminal region of SecA when associated with SecYEG in active complexes.” Protein Sci. 27(3):681-691. doi:10.1002/pro.3362  
  • Suo Y, Hardy SJS, Randall LL. (2015). “The basis of asymmetry in the SecA:SecB complex.” J Mol Biol. 427(4):887-900. doi:10.1016/j.jmb.2014.12.008 [PubMed]
  • Mao C, Cheadle CE, Hardy SJ, Lilly AA, Suo Y, Sanganna Gari RR, King GM, Randall LL. (2013). “Stoichiometry of SecYEG in the active translocase of Escherichia coli varies with precursor species.” Proc Natl Acad Sci U S A. 110(29):11815-20. doi:10.1073/pnas.1303289110 [PubMed]
  • Sanganna Gari RR, Frey NC, Mao C, Randall LL, King GM. (2013). “Dynamic structure of the translocon SecYEG in membrane: direct single molecule observations.” J Biol Chem. 288(23):16848-54. doi:10.1074/jbc.M113.471870 [PubMed]
  • Suo Y, Hardy SJ, Randall LL. (2011). “Orientation of SecA and SecB in complex, derived from disulfide cross-linking.” J Bacteriol. 193(1):190-6. doi:10.1128/JB.00975-10 [PubMed]
  • Randall LL, Henzl MT. (2010). “Direct identification of the site of binding on the chaperone SecB for the amino terminus of the translocon motor SecA.” Protein Sci. 19(6):1173-9. doi:10.1002/pro.392 [PubMed]
  • Crane JM, Lilly AA, Randall LL. (2010).  “Characterization of interactions between proteins using site-directed spin labeling and electron paramagnetic resonance spectroscopy.” Methods Mol Biol. 619:173-90. doi:10.1007/978-1-60327-412-8_11 [PubMed]
  • Lilly AA, Crane JM, Randall LL. (2009). “Export chaperone SecB uses one surface of interaction for diverse unfolded polypeptide ligands.” Protein Sci. 18(9):1860-8. doi:10.1002/pro.197 [PubMed]
  • Randall, L.L. and Hardy, S.J.S.  (1995) “High selectivity with low specificity: how SecB has solved the paradox of chaperone binding.”  Trends in Biochem Sci 20:65-69. DOI:https://doi.org/10.1016/S0968-0004(00)88959-8

References

  1. ^ a b "Linda Randall". University of Missouri. Retrieved December 4, 2018.
  2. ^ a b c d "Linda Randall". National Academy of Sciences. Retrieved December 4, 2018.
  3. ^ "Biochemists Elected to the National Academy of Sciences" (PDF). Washington State University Biochemistry Department. 1997. Retrieved December 4, 2018.
  4. ^ Smith, Debra (September 22, 2000). "Departing Professors Have Harsh Words for WSU". The Lewiston Tribune. Retrieved December 4, 2018.
  5. ^ a b c d "Linda Randall". University of Missouri Biochemistry Department. Retrieved December 4, 2018.
  6. ^ "American Academy of Arts and Sciences Announces 2004 Fellows and Foreign Hnorary Members". April 30, 2004. Retrieved December 4, 2018.
  7. ^ "Eli Lilly and Company Elanco Research Award Past Laureates". American Society for Microbiology. Retrieved December 4, 2018.

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