In 2016, she played on the gold medal-winning Chinese team in the women's event of the Asian Nations Cup in Dubai.[8] She was awarded the full Grandmaster title in March 2017.[9] In June, Lei won the 6th Chinese Women's Masters Tournament in Wuxi, ahead of Women's World Champion Tan Zhongyi.[10] In December, Lei took the silver medal in the Women's World Rapid Chess Championship in Riyadh.[11]
In April 2023, she won the Women's Candidates Tournament 2022-23 after beating Tan Zhongyi 3½–1½, winning the match by game 5. In July 2023, Lei challenged reigning Women's World Champion Ju Wenjun for the title, but lost the match after a loss in game 12.[14]