At the Web.com Tour qualifying tournament in December 2016, Griffin missed qualification by just one stroke.[4] Nonetheless, this enabled him to enter tournaments in 2017 as a reserve and to be eligible for a place in the reorder category.
Griffin won the Nashville Golf Open in June 2017, becoming the first player on tour in 13 years to win an event after making the cut on the number.[5] He finished 23rd on the regular season Web.com Tour money list to secure his PGA Tour card for the 2017–18 season.
During the 2017–18 PGA season Griffin finished 171st in FedEx points.
Griffin played on the Korn Ferry Tour during its 2019 season and finished 6th overall for the regular season (The 25) driven by consistent performance and a win at the Robert Trent Jones Golf Trail Championship, earning him a spot on the PGA Tour for the second time.