Nisar started his political career after returning to home from the United Kingdom. He contested his first-ever election in 1966 and was elected as the member of parliament for West Pakistan. Later, he contested in 1985 Pakistani general election as an independent candidate and was elected as the member of National Assembly of Pakistan until the next elections. During the period, he served adviser to the federal government for health and railways ministries. He is also credited for his contribution to the Pakistan Peoples Party's formation. On the occasion of a political speech against Ayub Khan delivered by then Pakistan's 16th prime minister Zulfikar Ali Bhutto, Nisar was inspired by the speech which was aimed at on the Tashkent Declaration and he subsequently joined the party. However, he later disassociated himself from the party over Bhutto's policies against farmers, and later he formed the Zamindar Tehreek (Farmer's movement) party aimed at to oppose political agenda of Bhutto.