Protein-coding gene in the species Homo sapiens
Leucine-rich repeats and immunoglobulin-like domains protein 1 [ 5] protein that in humans is encoded by the LRIG1 gene .[ 6] [ 7] [ 8] transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR family [ 9] MET [ 10] RET .[ 11]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000144749 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030029 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ GeneCards Human Gene Database. "LRIG1 Gene - GeneCards | LRIG1 Protein | LRIG1 Antibody" . www.genecards.org . Archived from the original on 2025-08-14. Retrieved 2025-11-16 . ^ Nilsson J, Vallbo C, Guo D, Golovleva I, Hallberg B, Henriksson R, Hedman H (Jun 2001). "Cloning, characterization, and expression of human LIG1". Biochem Biophys Res Commun . 284 (5): 1155– 61. Bibcode :2001BBRC..284.1155N . doi :10.1006/bbrc.2001.5092 . PMID 11414704 . ^ Hedman H, Nilsson J, Guo D, Henriksson R (Sep 2002). "Is LRIG1 a tumour suppressor gene at chromosome 3p14.3?" . Acta Oncol . 41 (4): 352– 4. doi :10.1080/028418602760169398 PMID 12234026 . S2CID 34357648 . ^ "Entrez Gene: LRIG1 leucine-rich repeats and immunoglobulin-like domains 1" .^ Gur G, Rubin C, Katz M, et al. (2005). "LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation" . EMBO J . 23 (16): 3270– 81. doi :10.1038/sj.emboj.7600342 . PMC 514515 PMID 15282549 . ^ Shattuck DL, Miller JK, Laederich M, et al. (2007). "LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy" . Mol. Cell. Biol . 27 (5): 1934– 46. doi :10.1128/MCB.00757-06 . PMC 1820466 PMID 17178829 . ^ Ledda F, Bieraugel O, Fard SS, Vilar M, Paratcha G (2008). "Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF" . J. Neurosci . 28 (2): 39– 49. doi :10.1523/JNEUROSCI.2196-07.2008 PMC 6671136 PMID 18171921 .
Further reading
Suzuki Y, Sato N, Tohyama M, et al. (1996). "cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains" . J. Biol. Chem . 271 (37): 22522– 7. doi :10.1074/jbc.271.37.22522 PMID 8798419 . Suzuki Y, Miura H, Tanemura A, et al. (2002). "Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia" . FEBS Lett . 521 (1– 3): 67– 71. doi :10.1016/S0014-5793(02)02824-7 PMID 12067728 . S2CID 5634836 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Nilsson J, Starefeldt A, Henriksson R, Hedman H (2004). "LRIG1 protein in human cells and tissues". Cell Tissue Res . 312 (1): 65– 71. doi :10.1007/s00441-003-0697-1 . PMID 12684867 . S2CID 7060595 . Thomasson M, Hedman H, Guo D, et al. (2003). "LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT–PCR and immunohistochemical analysis" . Br. J. Cancer . 89 (7): 1285– 9. doi :10.1038/sj.bjc.6601208 . PMC 2394322 PMID 14520461 . Gur G, Rubin C, Katz M, et al. (2005). "LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation" . EMBO J . 23 (16): 3270– 81. doi :10.1038/sj.emboj.7600342 . PMC 514515 PMID 15282549 . Laederich MB, Funes-Duran M, Yen L, et al. (2004). "The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases" . J. Biol. Chem . 279 (45): 47050– 6. doi :10.1074/jbc.M409703200 PMID 15345710 . {{cite journal }}: CS1 maint: numeric names: authors list (link )Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ljuslinder I, Malmer B, Golovleva I, et al. (2006). "Increased copy number at 3p14 in breast cancer" . Breast Cancer Res . 7 (5): R719–27. doi :10.1186/bcr1279 PMC 1242137 PMID 16168117 . Jensen KB, Watt FM (2006). "Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence" . Proc. Natl. Acad. Sci. U.S.A . 103 (32): 11958– 63. Bibcode :2006PNAS..10311958J . doi :10.1073/pnas.0601886103 PMC 1567680 PMID 16877544 . Shattuck DL, Miller JK, Laederich M, et al. (2007). "LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy" . Mol. Cell. Biol . 27 (5): 1934– 46. doi :10.1128/MCB.00757-06 . PMC 1820466 PMID 17178829 .
