Kv channel interacting protein

Kv channel interacting proteins are members of a family of voltage-gated potassium (K_v) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.^[1] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native K_v4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.^[2]

Members of this family include:

• KCNIP1, a protein that in humans is encoded by the KCNIP1 gene.^[3][2]
• KCNIP2, a protein that in humans is encoded by the KCNIP2 gene.^[3][2]
• KCNIP3, more commonly known as Calsenilin, a protein that in humans is encoded by the KCNIP3 gene.^[4][5][2]
• KCNIP4, a protein that in humans is encoded by the KCNIP4 gene.^[6][7][2]

References

1. Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.
2. "Entrez Gene: KCNIP1 Kv channel interacting protein 1".
3. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–556. Bibcode:2000Natur.403..553A. doi:10.1038/35000592. PMID 10676964. S2CID 4419472.
4. Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W (October 1998). "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment". Nat Med. 4 (10): 1177–81. doi:10.1038/2673. PMID 9771752. S2CID 10799492.
5. Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR (March 1999). "DREAM is a Ca2+-regulated transcriptional repressor". Nature. 398 (6722): 80–4. Bibcode:1999Natur.398...80C. doi:10.1038/18044. PMID 10078534. S2CID 204991618.
6. Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME, Jurman ME, Lawson D, Silos-Santiago I, Xie Y, Covarrubias M, Rhodes KJ, Distefano PS, An WF (Jan 2002). "Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain". Proc Natl Acad Sci U S A. 99 (2): 1035–40. Bibcode:2002PNAS...99.1035H. doi:10.1073/pnas.022509299. PMC 117799. PMID 11805342.
7. Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T (Apr 2002). "Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4". J Biol Chem. 277 (17): 14965–75. doi:10.1074/jbc.M200897200. PMID 11847232.