Kenneth H. Wolfe
Irish geneticist and academic
Kenneth Henry Wolfe FRS MRIA [ 11] [ 12] is an Irish geneticist and professor of genomic evolution at University College Dublin (UCD), Ireland .[ 13] [ 11] [ 14]
Education
Wolfe was educated at Trinity College Dublin , where he was awarded Bachelor of Arts degree in genetics in 1986[ 3] followed by a PhD in 1990[ 6] for research investigating synonymous substitution in vascular plants and mammals supervised by Paul M. Sharp .[ 4] [ 5] [ 6] [ 15]
Research and career
Wolfe's research focuses on comparative genomics , yeast genetics and bioinformatics .[ 2] [ 16] [ 17] Work in his laboratory investigates the evolution of eukaryotic genomes and chromosome organisation.[ 12] He is best known for his discovery that the genome of the yeast Saccharomyces cerevisiae underwent complete genome duplication about 100 million years ago,[ 18] an event that is now known to be the result of hybridization between two divergent species .[ 12] This finding reshaped our understanding both of yeast biology , and of mechanisms of genome evolution in eukaryotes.[ 12] His subsequent discoveries of similar ancient genome duplications (paleopolyploidy) [ 19] during human evolution , and in almost all families of flowering plants , led to the realisation that whole-genome duplication is widespread.[ 12] His group also studies the origin and evolution of mating systems in yeasts, and the process of mating-type switching in which one cell type can change into another by moving or replacing a section of chromosome.[ 12]
Wolfe was a postdoctoral researcher with Jeffrey D. Palmer [ 7] at Indiana University Bloomington before returning to Ireland in 1992 to establish his research group in the genetics department of Trinity College Dublin,[ 20] [ 3] where he remained for over 20 years. In 2013, he moved to University College Dublin 's UCD School of Medicine and Conway Institute.[ 21] As of 2017[update] his most highly cited peer reviewed papers[ 2] [ 14] [ 16] have been published in leading scientific journals including Nature ,[ 18] [ 22] PNAS ,[ 23] The Plant Cell ,[ 19] [ 24] Genome Research [ 25] and Nature Reviews Genetics .[ 7]
Former doctoral students from the Wolfe lab include Mario A. Fares,[ 4] Aoife McLysaght ,[ 4] [ 8] [ 9] Kevin P. Byrne,[ 4] Estelle Proux-Wéra[ 4] and Cathal Seoighe.[ 5] [ 10]
Awards and honours
Wolfe was elected a Fellow of the Royal Society (FRS) in 2017 ,[ 12] a member of the Royal Irish Academy (MRIA) in 2000[ 11] and a member of the European Molecular Biology Organization (EMBO) in 2010.[ 1] In 2011 he served as president of the Society for Molecular Biology and Evolution (smbe.org) .[ 26]
References
^ a b Anon (2010). "EMBO member: Kenneth H. Wolfe" . people.embo.org . Heidelberg: European Molecular Biology Organization . Archived from the original on 31 January 2017.
^ a b c Kenneth H. Wolfe publications indexed by Google Scholar
^ a b c Ken Wolfe's ORCID 0000-0003-4992-4979
^ a b c d e f g h i Anon (2017). "Kenneth H. Wolfe academic genealogy" . academictree.org . Archived from the original on 11 July 2017.
^ a b c d Kenneth H. Wolfe at the Mathematics Genealogy Project
^ a b c Wolfe, Kenneth H. (1990). Rates of nucleotide substitution in higher plants and mammals (PhD thesis). Trinity College Dublin. OCLC 842511087 . Copac 11666046 .
^ a b c Wolfe, Kenneth H. (2001). "Yesterday's polyploids and the mystery of diploidization". Nature Reviews Genetics . 2 (5): 333–341. doi :10.1038/35072009 . ISSN 1471-0056 . PMID 11331899 . S2CID 20796914 . (subscription required)
^ a b McLysaght, Aoife (2002). Evolution of vertebrate genome organisation (PDF) (PhD thesis). Trinity College Dublin. OCLC 842498402 . Copac 11660313 . Archived from the original (PDF) on 6 November 2017.
^ a b Wolfe, Ken (2017). "Wolfe lab alumni" . wolfe.ucd.ie . Archived from the original on 11 July 2017.
^ a b Seoighe, Cathal (2000). Gene order evolution and genomic analysis of the model eukaryote, Saccharomyces cerevisiae, and other yeast species (PhD thesis). Trinity College Dublin. OCLC 842501444 . Copac 11661350 ProQuest 301607379 .
^ a b c Anon (2000). "Kenneth H. Wolfe FTCD" . ria.ie . Dublin: Royal Irish Academy . Archived from the original on 11 December 2017. Retrieved 14 July 2017 .
^ a b c d e f g Anon (2017). "Professor Kenneth Wolfe FRS" . royalsociety.org . London: Royal Society . Archived from the original on 5 May 2017. One or more of the preceding sentences incorporates text from the royalsociety.org website where: "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License ." --"Royal Society Terms, conditions and policies" . Archived from the original on 11 November 2016. Retrieved 9 March 2016 .{{cite web }}
: CS1 maint: bot: original URL status unknown (link )
^ UCD Professor Kenneth Wolfe elected Fellow of the Royal Society on YouTube , University College Dublin
^ a b Kenneth H. Wolfe publications from Europe PubMed Central
^ Sharp, Paul M.; Cowe, Elizabeth; Higgins, Desmond G. ; Shields, Denis C.; Wolfe, Kenneth H.; Wright, Frank (1988). "Codon usage patterns in Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogaster and Homo sapiens; a review of the considerable within-species diversity" . Nucleic Acids Research . 16 (17): 8207–8211. doi :10.1093/nar/16.17.8207 . ISSN 0305-1048 . PMC 338553 . PMID 3138659 .
^ a b Kenneth H. Wolfe publications indexed by the Scopus bibliographic database. (subscription required)
^ Sherlock, Gavin; Schröder, Markus S.; Martinez de San Vicente, Kontxi; Prandini, Tâmara H. R.; Hammel, Stephen; Higgins, Desmond G. ; Bagagli, Eduardo; Wolfe, Kenneth H.; Butler, Geraldine (2016). "Multiple Origins of the Pathogenic Yeast Candida orthopsilosis by Separate Hybridizations between Two Parental Species" . PLOS Genetics . 12 (11): e1006404. doi :10.1371/journal.pgen.1006404 . ISSN 1553-7404 . PMC 5091853 . PMID 27806045 .
^ a b Wolfe, Kenneth H.; Shields, Denis C. (1997). "Molecular evidence for an ancient duplication of the entire yeast genome" . Nature . 387 (6634): 708–713. Bibcode :1997Natur.387..708W . doi :10.1038/42711 . ISSN 0028-0836 . PMID 9192896 . S2CID 4307263 . (subscription required)
^ a b Blanc, Guillaume; Wolfe, Kenneth H. (2004). "Widespread Paleopolyploidy in Model Plant Species Inferred from Age Distributions of Duplicate Genes" . The Plant Cell . 16 (7): 1667–1678. doi :10.1105/tpc.021345 . ISSN 1040-4651 . PMC 514152 . PMID 15208399 .
^ "Trinity College Dublin Genetics Department" . www.tcd.ie .
^ "Ken Wolfe Profile" . people.ucd.ie .
^ Lander, E. S. ; Linton, M.; Birren, B.; Nusbaum, C.; Zody, C.; Baldwin, J.; Devon, K.; Dewar, K.; Doyle, M.; Fitzhugh, W.; Funke, R.; Gage, D.; Harris, K.; Heaford, A.; Howland, J.; Kann, L.; Lehoczky, J.; Levine, R.; McEwan, P.; McKernan, K.; Meldrim, J.; Mesirov, J. P. ; Miranda, C.; Morris, W.; Naylor, J.; Raymond, C.; Rosetti, M.; Santos, R.; Sheridan, A.; et al. (2001). "Initial sequencing and analysis of the human genome" (PDF) . Nature . 409 (6822): 860–921. Bibcode :2001Natur.409..860L . doi :10.1038/35057062 . hdl :2027.42/62798 . ISSN 0028-0836 . PMID 11237011 .
^ Wolfe, K. H.; Li, W. H.; Sharp, P. M. (1987). "Rates of nucleotide substitution vary greatly among plant mitochondrial, chloroplast, and nuclear DNAs" . Proceedings of the National Academy of Sciences . 84 (24): 9054–9058. Bibcode :1987PNAS...84.9054W . doi :10.1073/pnas.84.24.9054 . ISSN 0027-8424 . PMC 299690 . PMID 3480529 .
^ Blanc, Guillaume; Wolfe, Kenneth H. (2004). "Functional Divergence of Duplicated Genes Formed by Polyploidy during Arabidopsis Evolution" . The Plant Cell . 16 (7): 1679–1691. doi :10.1105/tpc.021410 . ISSN 1040-4651 . PMC 514153 . PMID 15208398 .
^ Blanc, G.; Hokamp, Karsten; Wolfe, Kenneth H. (2003). "A Recent Polyploidy Superimposed on Older Large-Scale Duplications in the Arabidopsis Genome" . Genome Research . 13 (2): 137–144. doi :10.1101/gr.751803 . ISSN 1088-9051 . PMC 420368 . PMID 12566392 .
^ Anon (2017). "SMBE Council members" . smbe.org . Archived from the original on 10 October 2017. Retrieved 22 September 2017 .