Bowersox's first mission was STS-50 aboard the Columbia, where he served as the pilot.[6] The mission launched on June 25, 1992, from Launch Complex 39A at the Kennedy Space Center, Florida at 16:12:23 UTC.[7]: 2 Its primary objective was to conduct experiments in the U.S. Microgravity Laboratory 1 (USML-1), a Spacelab module dedicated to the study of microgravity. This module housed experiments related to fluid dynamics, crystal growth, combustion, and biological processes.[7]: 23–26
The mission concluded with a landing at the Shuttle Landing Facility, Florida on July 9, 1992, at 11:42:27 UTC.[7]: 5
Bowersox's second mission was STS-61 aboard the Endeavour, in which he served as the pilot.[8] The mission was launched on December 2, 1993, from Launch Complex 39B at 09:27:00 UTC.[9]: 2 The mission's primary objective was the first servicing of the Hubble Space Telescope, during which astronauts performed a series of spacewalks to repair and upgrade the telescope's systems, thereby restoring its optical performance and extending its operational lifespan.[9]: 1 STS-61 concluded with the Endeavour landing successfully at the Shuttle Landing Facility on December 13, 1993, at 05:25:37 UTC.[9]: 4
Bowersox's third mission was STS-73 aboard the Columbia, where he served for the first time as the mission commander.[10] The mission was launched on October 20, 1995, from Launch Complex 39B at 13:53:00 UTC.[11]: 3 STS-73's primary objective was to conduct a series of experiments in the U.S. Microgravity Laboratory-2 (USML-2), focusing on materials science, biotechnology, combustion science, and fluid mechanics in the unique microgravity environment of space.[11] The mission concluded with Columbia landing successfully at the Shuttle Landing Facility on November 5, 1995, at 11:45:21 UTC.[11]: 8
Bowersox's fourth mission in space was STS-82 aboard the Discovery, where he served as the mission commander. The mission launched on February 11, 1997, from Launch Complex 39A at 08:55:17 UTC.[12]: 3 STS-82 was the second servicing mission to the Hubble Space Telescope.[13] During the mission, astronauts performed a series of spacewalks to install new instruments and conduct repairs on the telescope.
The tasks undertaken aimed to enhance the telescope's operational capabilities. Following the completion of its objectives, STS-82 concluded with Discovery landing at the Shuttle Landing Facility on February 21, 1997, at 08:32:00 UTC.[13]
Bowersox served as the commander of Expedition 6 to the International Space Station (ISS). Alongside him were crewmates Nikolai Budarin and Donald Pettit.[14] As commander, Bowersox was responsible for the overall success of the mission and the safety of his crew.[15]
The expedition commenced with the crew's launch aboard the Space Shuttle Endeavour from Launch Complex 39A on November 23, 2002, at 00:49 UTC.[14] They docked with the ISS on November 25, 2002, at 21:59 UTC.[16] During their stay, the crew conducted several scientific experiments in the microgravity of space and performed two spacewalks to continue outfitting and maintenance on the ISS.[15] Originally set to return aboard STS-114, the Expedition 6 crew's descent was shifted to the Russian Soyuz TMA-1 spacecraft due to the Columbia tragedy. They landed near Arkalyk, Kazakhstan, on May 4, 2003, at 02:04 UTC.[17]
After NASA
Bowersox retired from NASA on September 30, 2006. On June 16, 2009 he was appointed vice president of Astronaut Safety and Mission Assurance at SpaceX. He was inducted into the Astronaut Hall of Fame on June 8, 2010, four days after the first successful launch of SpaceX's Falcon 9 rocket.[18][19]
It was reported on January 17, 2012, that Bowersox resigned from SpaceX in late December 2011.
Bowersox appeared on three episodes of the American TV show Home Improvement. Series 3, Episode 24, titled "Reality Bytes", aired 18 May 1994.
NASA administration
In July 2019, Bowersox became NASA's Acting Associate Administrator for the Human Exploration Operations Mission Directorate, replacing William Gerstenmaier.[20] In May 2020, Bowersox again became NASA's Acting Associate Administrator for the Human Exploration Operations Mission Directorate, replacing Douglas Loverro.[21]
In May 2023, Bowersox was named the associate administrator of the Space Operations Mission Directorate.[22]