In Season 1, Episode 2, "A Crying Need", on the television series Here Come the Brides, she appears as Dr. Allyn Wright, Seattle's first doctor who also happens to be female. The series ran from 1968 to 1970.
She was menaced in the Dissolve to Black (1961) episode of Roald Dahl's Way Out (1961) and appeared in The Invaders TV series as Ellen Woods (1967), supposedly deranged after seeing extraterrestrials in a barn near her town in the episode "Nightmare". She had a featured role in the HBO series Oz (1997, 2000).
Although she often appeared on stage New York theatre, Widdoes may be most widely known for her work in soap operas. She was an original cast member of Young Doctor Malone, playing Jill Malone (1958–59). She played lower middle class matriarch Rose Perrini on Another World (1978–80) and appeared for a short time on Ryan's Hope (1983) as the vindictive villainess Una McCurtain, a character seeking revenge on Maeve Ryan as part of an old family feud.
Her best known work was as Emma Snyder on As the World Turns. Emma was the matriarch of the Snyder family, introduced to the show's canvas in 1985. The Snyders were based on the family of then-head writer Douglas Marland. She was prominently featured during the show's 50th anniversary program in April 2006 and continued to make regular appearances until the series finale year (although she was noticeably absent during the last few months).