KT5720

KT5720

Names
IUPAC name (5R,6S,8S)-Hexyl 6-hydroxy-5-methyl-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-6-carboxylate
Other names KT 5720
Identifiers
CAS Number	108068-98-0^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:85085^N
ChemSpider	399960^N
ECHA InfoCard	100.238.838
PubChem CID	454202
UNII	58HV29I28S^N
CompTox Dashboard (EPA)	DTXSID40910614
InChI InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32+/m0/s1^N Key: ZHEHVZXPFVXKEY-RUAOOFDTSA-N^N InChI=1/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32+/m0/s1 Key: ZHEHVZXPFVXKEY-RUAOOFDTBS
SMILES CCCCCCOC(=O)[C@@]1(C[C@H]2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)[C@@]1(O2)C)CNC6=O)O
Properties
Chemical formula	C32H31N3O5
Molar mass	537.616 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references

KT5720 is a kinase inhibitor with specificity towards protein kinase A.^[1] It is a semi-synthetic derivative of K252a^[2] and analog of staurosporine.

References

1. Makarevich, A. V.; Sirotkin, A. V.; Rafay, J. (2010). "Comparison of Effects of Protein Kinase A, Mitogen-activated Protein Kinase, and Cyclin-dependent Kinase Blockers on Rabbit Ovarian Granulosa Cell Functions". Hormone and Metabolic Research. 42 (13): 936–43. doi:10.1055/s-0030-1267226. PMID 20972940.
2. CID 3844 from PubChem