KATNB1

KATNB1
Identifiers
Aliases	KATNB1, KAT, LIS6, katanin regulatory subunit B1
External IDs	OMIM: 602703; MGI: 1921437; HomoloGene: 4302; GeneCards: KATNB1; OMA:KATNB1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q21 Start 57,735,739 bp[1] End 57,757,244 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C5 Start 95,807,814 bp[2] End 95,829,777 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus right frontal lobe right uterine tube Brodmann area 23 oocyte prefrontal cortex primary visual cortex Brodmann area 9 endothelial cell Brodmann area 10 Top expressed in seminiferous tubule spermatid spermatocyte yolk sac visual cortex primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell granulocyte internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein heterodimerization activity microtubule-severing ATPase activity microtubule binding dynein complex binding protein binding Cellular component cytoplasm microtubule organizing center growth cone nucleus axon spindle pole membrane centrosome midbody microtubule soma microtubule cytoskeleton plasma membrane cytoskeleton katanin complex cytosol spindle Biological process positive regulation of neuron projection development cell cycle negative regulation of microtubule depolymerization cell division protein targeting microtubule severing positive regulation of cell death positive regulation of microtubule depolymerization microtubule depolymerization mitotic chromosome movement towards spindle pole Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10300 74187 Ensembl ENSG00000140854 ENSMUSG00000031787 UniProt Q9BVA0 Q8BG40 RefSeq (mRNA) NM_005886 NM_028805 RefSeq (protein) NP_005877 NP_083081 Location (UCSC) Chr 16: 57.74 – 57.76 Mb Chr 8: 95.81 – 95.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Katanin p80 WD40-containing subunit B1 is a protein that in humans is encoded by the KATNB1 gene.^[5][6]

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.^[6] KATNB1 is associated with microlissencephaly.

References

1. GRCh38: Ensembl release 89: ENSG00000140854 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031787 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ (May 1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit". Cell. 93 (2): 277–87. doi:10.1016/S0092-8674(00)81578-0. PMID 9568719. S2CID 13583382.
6. "Entrez Gene: KATNB1 katanin p80 (WD repeat containing) subunit B 1".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Toyo-Oka K, Sasaki S, Yano Y, et al. (2006). "Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration". Hum. Mol. Genet. 14 (21): 3113–28. doi:10.1093/hmg/ddi339. PMID 16203747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Karabay A, Yu W, Solowska JM, et al. (2004). "Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules". J. Neurosci. 24 (25): 5778–88. doi:10.1523/JNEUROSCI.1382-04.2004. PMC 6729225. PMID 15215300.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• McNally KP, Bazirgan OA, McNally FJ (2000). "Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin". J. Cell Sci. 113 (9): 1623–33. doi:10.1242/jcs.113.9.1623. PMID 10751153.
• Ahmad FJ, Yu W, McNally FJ, Baas PW (1999). "An essential role for katanin in severing microtubules in the neuron". J. Cell Biol. 145 (2): 305–15. doi:10.1083/jcb.145.2.305. PMC 2133110. PMID 10209026.
• McNally FJ, Thomas S (1999). "Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs". Mol. Biol. Cell. 9 (7): 1847–61. doi:10.1091/mbc.9.7.1847. PMC 25426. PMID 9658175.
• McNally FJ, Okawa K, Iwamatsu A, Vale RD (1997). "Katanin, the microtubule-severing ATPase, is concentrated at centrosomes". J. Cell Sci. 109 (3): 561–7. doi:10.1242/jcs.109.3.561. PMID 8907702.
• McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase that severs and disassembles stable microtubules". Cell. 75 (3): 419–29. doi:10.1016/0092-8674(93)90377-3. PMID 8221885. S2CID 10264319.
• Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW (1984). "Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions". Mol. Cell. Biol. 3 (10): 1738–45. doi:10.1128/mcb.3.10.1738. PMC 370035. PMID 6646120.

External links

• KATNB1 human gene location in the UCSC Genome Browser.
• KATNB1 human gene details in the UCSC Genome Browser.