Layne entered his freshman season at Michigan State in 2016 as a wide receiver but was converted into a cornerback prior to the fifth game of the season.[3] During his career, he played in 34 games and had 130 tackles, three interceptions, 0.5 sacks and one touchdown. After his junior season, Layne entered the 2019 NFL draft.[4]
Layne was drafted by the Pittsburgh Steelers in the third round (83rd overall) of the 2019 NFL Draft.[7] He briefly appeared in 10 games in 2019, getting only 3 tackles on the season.
Layne was placed on the reserve/COVID-19 list by the Steelers on July 29, 2020.[8] He was activated on August 11, 2020.[9] He appeared in all 16 games for the Steelers, and collected 22 tackles on the year. On August 30, 2022, he was released by the Steelers.[10]
New York Giants
On August 31, 2022, Layne was claimed off waivers by the New York Giants.[11] On November 14, 2022, he was waived.[12]
Chicago Bears
On November 15, 2022, the Chicago Bears claimed Layne off waivers.[13] He was waived on December 20.[14]
Carolina Panthers
On December 21, 2022, Layne was claimed off waivers by the Carolina Panthers, but did not report to the team.[15] He was released on March 8, 2023.