Ramírez turned professional in 2012 and has been promoted by Bob Arum as a Top Rank fighter since the same year.[4][5]
After compiling a perfect 15-0 record, Ramírez beat Johnny Garcia by unanimous decision on December 5, 2015 to win the vacant WBC Continental Americas light welterweight title.[6] He would go on to defend the title a total of four times.[7]
WBC light welterweight champion
Ramírez vs. Imam
On March 17, 2018, Ramírez defeated Amir Imam by unanimous decision with scores of 120-108, 117-111 and 115-113 to win the vacant WBC super lightweight title. Ramírez had badly swelled Imam's right eye and landed all kinds of hard punches throughout the fight.[8]
Ramírez vs. Orozco
In his next fight, Ramírez faced Antonio Orozco, then #3 by the WBC at light welterweight, at the Save Mart Center in Fresno, California.[9] In an action-packed fight, the defending champion managed to drop his opponent twice, once in the fourth, and once in the eighth round. Despite the two knockdowns, Orozco gave his all and even was the aggressor at times. In the end, it was a clear win for Ramírez, all three judges scoring the fight 119-107 in favor of the champion.[10]
Ramírez vs. Zepeda
In his next title defense, Ramírez faced Jose Zepeda, ranked #14 by the WBC at light welterweight.[11] Zepeda was winning the early rounds of the fight. Ramírez started to gain control of the fight in the fourth round. Ramírez finished the fight strong, especially in the last 20 seconds, unleashing power shots on Zepeda. Ramírez won the fight via majority decision in a very competitive fight.[12]
Unified light welterweight champion
Ramírez vs. Hooker
On July 27, 2019, Ramírez fought undefeated WBO light welterweight champion Maurice Hooker in a unification fight. In an action-packed fight, Ramírez first managed to drop Hooker in the opening round, and despite replays showing that Ramírez had stepped on Hooker's foot, it was ruled an official knockdown. As the rounds went on, the fight slowed down, which seemed to favor Hooker. However, in the sixth round, Ramírez connected on a left hand to the chin, followed by another big left to the head, which sent Hooker reeling against the ropes. As Hooker was helpless, the referee stopped the fight with 1:48 to go in the round, awarding Ramírez the technical knockout victory.[13]
Ramírez vs. Postol
On August 29, 2020, Ramírez defended his WBC and WBO titles against former WBC champion Viktor Postol, winning a majority decision with scores of 116-112, 115-113, 114-114.[14]
On May 22, 2021, Ramírez attempted to become the first undisputed champion of Mexican descent when he faced undefeated unified champion Josh Taylor in Paradise, Nevada in a showdown for the undisputed light welterweight championship. Ramírez was knocked down twice in the sixth and seventh rounds, both times by Taylor's left hand, and ultimately lost by unanimous decision with all three judges scoring the bout 114-112 in favor of Taylor.[15]
Continued light welterweight career
Ramírez vs. Pedraza
On October 30, 2021, it was revealed that Ramírez would face the former two-weight world champion José Pedraza on February 5, 2022, in the main event of an ESPN broadcast Top Rank card.[16] The bout was later postponed for March 4, as Pedraza fell ill with flu-like symptoms. Ramirez won the bout by unanimous decision in a competitive fight, By all judges scoring it 116-112.[17]
Ramírez vs. Barthelemy
Ramírez was scheduled to face Rances Barthelemy on April 27, 2024 at Save Mart Center in Fresno, CA.[18] The outing was his first fight promoted by Golden Boy.[19] Ramírez won the fight by unanimous decision.[20]