John Palaiologos (Greek : Ἱωάννης Παλαιολόγος ; 1286–1307) was a son of the Byzantine Emperor Andronikos II Palaiologos (reigned 1282–1328) and his second wife, Irene of Montferrat .
He received the supreme courtly dignity of Despot on 22 May 1295, and married Irene Palaiologina Choumnaina , the daughter of Nikephoros Choumnos , in 1303. The pair did not have any children. From 1304, he served as governor of Thessalonica , where he made donations of property to the Hodegetria Monastery . In 1305, the throne of the March of Montferrat became vacant and his mother wanted to send John to take it up, but was successfully opposed by the Patriarch of Constantinople , Athanasius I , so that John's younger brother Theodore was sent instead. John Palaiologos died in 1307 in Thessalonica. In 1321, his body was transferred to Constantinople and buried in the Pantokrator Monastery .
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