Professor Emeritus of Anatomy and Molecular Biology
For other people called John White, see
John White .
John Graham White FRS [ 7] (born 1943)[ 3] is an Emeritus Professor of Anatomy and Molecular Biology [ 3] [ 2] [ 8] at the University of Wisconsin–Madison .[ 9] [ 10] [ 11] His research interests are in the biology of the model organism Caenorhabditis elegans and laser microscopy .[ 12]
Education
White was educated at Brunel University , where he was awarded an undergraduate degree in Physics in 1969.[ 3] He went on to study for his PhD[ 13] at University of Cambridge in 1975 for work on computer-aided reconstruction of the nervous system of Caenorhabditis elegans supervised by Sydney Brenner .[ 3]
Research and career
After working at the Laboratory of Molecular Biology , White moved to the University of Wisconsin–Madison in 1993.[ 3] White's research investigates cell division in the nematode Caenorhabditis elegans .[ 14] [ 15] [ 16] [ 17] [ 18] With collaborators Sydney Brenner ,[ 19] [ 20] John Sulston [ 21] and others, White co-developed confocal microscopy and mapped the complete nervous system of Caenorhabditis elegans , consisting of 302 neurons and over 7000 synapses . The study was published in 1986 by the Philosophical Transactions of the Royal Society ,[ 20] and is considered[by whom? ] to be the first work in the emerging field of connectomes . More recently his research used:
two collaborative but distinct laboratories, one a biological laboratory that investigates cell division in the nematode Caenorhabditis elegans, and the other an interdisciplinary Biophotonics Instrumentation laboratory that develops new computational and optical techniques for live cell studies.[ 2]
White identified the first gene with a demonstrated role in determining synaptic specificity. He studied the role of cell–cell interaction in determining the lineage pattern, stimulating a wide field of research. In more recent work, White and his co-workers partially confirmed his earlier model of cytokinesis ; they discovered genes controlling cytokinesis and found features previously thought specific to plant cell division. Recognising the potentialities of laser-scanning confocal microscopy, White built a prototype microscope: with Brad Amos he developed this into a commercially produced instrument now widely used.[ 7] His former doctoral students include Richard Durbin , [ 4] other notable former students include Ahna Skop, Julie Ahringer [ 5] and Tony Hyman .[ 6]
Awards and honours
White was the recipient of the Mullard Award in 1994. He was elected a member of the European Molecular Biology Organization (EMBO) in 1994[ 1] and a Fellow of the Royal Society (FRS) in 2005 .[ 7]
The Center for Quantitative Cell Imaging at the University of Wisconsin-Madison hosts a biennial seminar series named in honor of John White. Featured speakers have included:
Personal life
White has been professor emeritus since he retired in 2008.[ 3]
References
^ a b Anon (1994). "John G. White" . people.embo.org .
^ a b c "White, John - UW-Engineering Directory, College of Engineering @ The University of Wisconsin-Madison" . Archived from the original on 9 December 2013.
^ a b c d e f g h i White, J. G. (2013). "Getting into the mind of a worm—a personal view" . WormBook : 1–10. doi :10.1895/wormbook.1.158.1 . PMC 4781474 . PMID 23801597 .
^ a b Durbin, Richard Michael (1987). Studies on the development and organisation of the nervous system of Caenorhabditis elegans (PhD thesis). University of Cambridge. EThOS uk.bl.ethos.233920 .
^ a b Malone, C. J.; Misner, L.; Le Bot, N.; Tsai, M. C.; Campbell, J. M.; Ahringer, J.; White, J. G. (2003). "The C. Elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus" . Cell . 115 (7): 825–836. doi :10.1016/S0092-8674(03)00985-1 . PMID 14697201 . S2CID 2605372 .
^ a b Anon (2022). "Anthony Hyman: Group Leader" . mpi-cbg.de . Max Planck Institute of Molecular Cell Biology and Genetics .
^ a b c Anon (2005). "Dr John White FRS" . London: royalsociety.org. Archived from the original on 17 November 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where: "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License ." --"Royal Society Terms, conditions and policies" . Archived from the original on 25 September 2015. Retrieved 9 March 2016 .{{cite web }}
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^ John G. White publications indexed by the Scopus bibliographic database. (subscription required)
^ Squirrell, J. M.; Wokosin, D. L.; White, J. G.; Bavister, B. D. (1999). "Long-term two-photon fluorescence imaging of mammalian embryos without compromising viability" . Nature Biotechnology . 17 (8): 763–767. doi :10.1038/11698 . PMC 5087329 . PMID 10429240 .
^ Kimble, J. E. ; White, J. G. (1981). "On the control of germ cell development in Caenorhabditis elegans". Developmental Biology . 81 (2): 208–219. doi :10.1016/0012-1606(81)90284-0 . PMID 7202837 .
^ Chalfie, M.; Eddy, S. ; Hengartner, M. O.; Hodgkin, J. ; Kohara, Y.; Plasterk, R. H.; Waterston, R. H.; White, J. G. (1995). "Genome maps. VI. Caenorhabditis elegans. Wall chart". Science . 270 (5235): 415–430. doi :10.1126/science.270.5235.410 . PMID 7569996 . S2CID 42933365 .
^ John G. White publications indexed by Google Scholar
^ White, John (1975). Computer aided reconstruction of the nervous system of Caenorhabditis elegans . cam.ac.uk (PhD thesis). University of Cambridge. OCLC 500588370 . EThOS 477040 .
^ Hyman, A. A.; White, J. G. (1987). "Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans" . The Journal of Cell Biology . 105 (5): 2123–2135. doi :10.1083/jcb.105.5.2123 . PMC 2114830 . PMID 3680373 .
^ Podbilewicz, B.; White, J. G. (1994). "Cell fusions in the developing epithelial of C. Elegans". Developmental Biology . 161 (2): 408–424. doi :10.1006/dbio.1994.1041 . PMID 8313992 .
^ White, J. ; Strome, S. (1996). "Cleavage plane specification in C. Elegans: How to divide the spoils" . Cell . 84 (2): 195–198. doi :10.1016/s0092-8674(00)80974-5 . PMID 8565065 .
^ O'Connell, K. F.; Leys, C. M.; White, J. G. (1998). "A genetic screen for temperature-sensitive cell-division mutants of Caenorhabditis elegans" . Genetics . 149 (3): 1303–1321. doi :10.1093/genetics/149.3.1303 . PMC 1460235 . PMID 9649522 .
^ Hird, S. N.; White, J. G. (1993). "Cortical and cytoplasmic flow polarity in early embryonic cells of Caenorhabditis elegans" . The Journal of Cell Biology . 121 (6): 1343–1355. doi :10.1083/jcb.121.6.1343 . PMC 2119718 . PMID 8509454 .
^ White, J. G.; Southgate, E.; Thomson, J. N.; Brenner, S. (1976). "The structure of the ventral nerve cord of Caenorhabditis elegans" . Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences . 275 (938): 327–348. Bibcode :1976RSPTB.275..327W . doi :10.1098/rstb.1976.0086 . PMID 8806 .
^ a b White, J. G. ; Southgate, E. ; Thomson, J. N.; Brenner, S. (1986). "The structure of the nervous system of the nematode Caenorhabditis elegans" . Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences . 314 (1165): 1–340. Bibcode :1986RSPTB.314....1W . doi :10.1098/rstb.1986.0056 . PMID 22462104 .
^ Sulston, J. ; Schierenberg, E.; White, J. G. ; Thomson, J. (1983). "The embryonic cell lineage of the nematode Caenorhabditis elegans". Developmental Biology . 100 (1): 64–119. doi :10.1016/0012-1606(83)90201-4 . PMID 6684600 .
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