Hugill signed with Premier League side Manchester United on 1 July 2020, with the Manchester club reportedly having fought off competition from Arsenal and Tottenham Hotspur, among others, for his signature.[3][6][7] His career in Manchester started brightly, with his most notable performance coming against Liverpool U23, where he scored four goals in a 6–3 win.[8][4][9] In doing so, he became only the second player in Manchester United history to score four in one game against Liverpool, after Steve Jones in a reserve game in 1977.[10]
Hugill was called up to train with the Manchester United first team for 2021–22 pre-season preparation.[11] He featured in friendly games against Derby County and Queens Park Rangers.[12]
On 1 February 2023, Hugill was one of three Manchester United youngsters to join National League club Altrincham on loan for the remainder of the season, alongside Sonny Aljofree and Maxi Oyedele.[13] This marked the start of a new scheme that would see the youngsters continue to train and play for Manchester United's academy teams, while also earning senior experience playing for their loan club.[14]
On 12 January 2024, he joined League One club Burton Albion on loan until the end of the season.[15] He made his debut three days later, scoring his side's equaliser within minutes of his introduction from the bench in an eventual 3–2 defeat to Derby County.[16]