In 2011, Vanendert showed good form at La Flèche Wallonne, where he came sixth. He rode the Tour de France initially as the main climbing domestique for Jurgen Van den Broeck. However, when his leader crashed out of the race, Vanendert was given a free role, and on Stage 14 attacked from the group of GC contenders to win the stage. Vanendert finished 20th overall and also wore the King of the Mountains Jersey.