Humphrey was born on March 15, 1812, in Steuben County, New York. On February 13, 1835, he married Sarah Bull. By trade, he was a sailor and a sea captain.
Humphrey was an alderman of Milwaukee in 1854 and 1855. Later, he was a member of the Assembly during the 1857 session. In 1877, he was Harbor Master of the Port of Milwaukee. Humphrey was a Democrat.[3]